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Severe, early-onset fetal growth restriction with absent or reversed end-diastolic umbilical artery velocities (FGRa/r) is marked by profound placental vascular insufficiency, yet the role of the villous stromal extracellular matrix (ECM) in this pathology remains poorly defined. Here, we applied an...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD070632 | Pride
Increased fibrotic extracellular matrix (ECM) deposition promotes tumor invasion, the first step of the metastatic cascade. Yet, the underlying mechanisms are poorly understood as conventional studies of tumor cell migration are often performed in 2D culture lacking the compositional and structural ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044029 | Pride
Blunted first-phase insulin secretion and insulin deficiency are early signs of -cell dysfunction and diabetes manifestation. Thus, insights into molecular mechanisms that regulate insulin homeostasis might provide entry sites to replenish insulin content and restore -cell function. Here, we identif...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD040758 | Pride
To characterise the metabolic landscape of metastatic breast cancer we investigated differences in metabolites between the serum of MMTV-PyMT mice (n=29) and their wild-type counterparts (n=9) (https://doi.org/10.1101/2024.07.02.601676). Uracil was identified as a metabolite that had a positive corr...
ORGANISM(S): Mus musculus 
2025-06-12 | GSE292203 | GEO
Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple sclerosis (MS). Currently there are no prognostic biological markers that accurately predict conversion of CIS to clinically definite MS (CDMS). Furthermore, the earliest molecular events in MS are still unk...
ORGANISM(S): Homo sapiens 
2008-11-26 | GSE13732 | GEO
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