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MetabolomicsIntegrated transcriptomic and metabolomic analysis reveals the regulatory role of Itaconic acid in inflammatory infiltration during myocardial Ischemia-Reperfusion injury

Following establishment of a myocardial ischemia-reperfusion model, tissue samples from the infarct border zone were harvested for transcriptomics and wide-target metabolomic sequencing. Bioinformatics methods were used to analyse the transcriptomics and metabolomics results separately and to per...

2025-10-14 | MTBLS12934 | MetaboLights
TranscriptomicsIntegrative genomic analysis identifies clinically relevant subtypes of head and neck cancer characterized by hypoxia, T-cell infiltration, and EMT
Current classification of head and neck squamous cell carcinomas (HNSCC) based on anatomic site and clinical stage fails to capture biologic heterogeneity or adequately inform treatment. Here we use consensus clustering on 371 HNSCC in three cohorts, including a new cohort of 134 patients with locor...
ORGANISM(S): Homo sapiens 
2015-03-04 | E-GEOD-40774 | biostudies-arrayexpress
ProteomicsMembrane proteomic profiling to identify candidate therapy targets for glioblastoma infiltration
Isocitrate dehydrogenase wild type glioblastoma (GBM) is an aggressive brain tumour characterized by rapid growth and infiltration into adjacent functional brain tissue. Presently, treatment is restricted to surgical resection followed by temozolomide chemotherapy and concomitant radiotherapy; howev...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD058999 | Pride
Membrane glioblastoma astrocyte infiltration 
TranscriptomicsPPARγ activation promotes infiltration of alternatively activated macrophages into adipose tissue.
Background: Obesity is associated with infiltration of macrophages into adipose tissue. Adipose macrophages may contribute to an elevated inflammatory status by secreting a variety of pro-inflammatory mediators, including TNFalpha and IL-6. Recent data suggest that during diet-induced obesity the ph...
ORGANISM(S): Mus musculus 
2008-04-29 | E-GEOD-11295 | biostudies-arrayexpress
ProteomicsSecretome analysis of Pancreatic Cancer Spheroid with myeloid cell infiltration
Pancreatic ductal adenocarcinoma (PDAC) is one of the most hypoxic, lethal, and treatment resistant cancers. Due to its desmoplastic and hypoxic nature along with the abundance of myeloid cell infiltration and scare T cell infiltration, PDAC is considered a cold tumor. Using MiaPaCA-2 as a PDAC sphe...
ORGANISM(S): Homo sapiens (Human) 
2023-12-15 | PXD044177 | Pride
Human Spheroid Pancreatic cancer Pdac Miapaca2 Lc-ms/ms 
GenomicsGaST-seq flg22 h2o infiltration
GaST-seq spatial transcriptomics flg22 h2o infiltration
PRJEB31312 | ENA
ProteomicsIncreased Nuclear Transporter IPO7 Contributes to the Tumor Growth and Correlates with CD8 T cell Infiltration in Cervical Cancer
Background: Importin 7 (IPO7), a karyopherin-β protein, is involved in various tumorigenesis and progression abilities by mediating the nuclear import of oncoproteins. However, the exact biological functions and IPO7 remain to be further elucidated. Materials and Methods: TCGA and GEO datasets were...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026995 | Pride
Immune infiltration Cervical cancer. Proteome Mass spectrometry Ipo7 
GenomicsImmune Infiltration in Aggressive Papillary Craniopharyngioma: High infiltration But Low Action
Immune Infiltration in Aggressive Papillary Craniopharyngioma: High infiltration But Low Action
PRJNA892989 | ENA
ProteomicsSpatially variant immune infiltration scoring in human cancer tissues
The Immunoscore is a method to quantify the immune cell infiltration within cancers to predict the disease prognosis. Previous immune profiling approaches relied on limited immune markers to establish patients’ tumor immunity. However, immune cells exhibit a higher-level complexity that is typically...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035340 | Pride
Lung cancer imc 
ProteomicsC1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse
Extramedullary infiltration (EMI) is a concomitant manifestation indicating poor prognosis of acute myeloid leukemia (AML), yet the underlying mechanism remains poorly understood and therapeutic options are limited. Here, we employed single-cell RNA sequencing on bone marrow (BM) and EMI samples fro...
ORGANISM(S): Homo Sapiens 
2022-08-03 | PXD035784 |
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