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ProteomicsImportin-7 Promotes Tension-Induced Osteogenesis by Regulating RUNX2 Nuclear Translocation during Orthodontic Tooth Movement
Orthodontic tooth movement (OTM) is primarily driven by alveolar bone remodeling, wherein tension-induced osteogenesis plays a central role. Importin7 (IPO7) has been identified as a highly mechanoresponsive nuclear transport receptor (NTR). However, its role in regulating tension-induced osteogenes...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-06 | PXD061760 | Pride
Runx2 Mechanotransduction Ipo7 Tooth movement Nuclear translocation Alveolar bone remodeling 
ProteomicsIncreased Nuclear Transporter IPO7 Contributes to the Tumor Growth and Correlates with CD8 T cell Infiltration in Cervical Cancer
Background: Importin 7 (IPO7), a karyopherin-β protein, is involved in various tumorigenesis and progression abilities by mediating the nuclear import of oncoproteins. However, the exact biological functions and IPO7 remain to be further elucidated. Materials and Methods: TCGA and GEO datasets were...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026995 | Pride
Immune infiltration Cervical cancer. Proteome Mass spectrometry Ipo7 
UnknownPancreatic Cancer Progression Is Regulated by IPO7/p53/LncRNA MALAT1/MiR-129-5p Positive Feedback Loop.
Not available
S-EPMC8517143 | biostudies-literature
ProteomicsSWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis.
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleevec, STI-571) is a selective inhibitor of Bcr-Abl activity highly effective in the treatment...
ORGANISM(S): Homo sapiens (Human) 
2018-07-30 | PXD007771 | Pride
Swath-ms  cml cells  curcumin 
UnknownSWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis.
Not available
S-EPMC6060558 | biostudies-literature
UnknownIncreased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Not available
S-EPMC8505702 | biostudies-literature
UnknownImportin-7 promotes tension-induced osteogenesis by regulating RUNX2 nuclear translocation during orthodontic tooth movement.
Not available
S-EPMC12475212 | biostudies-literature
UnknownImportin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus production.
Not available
S-EPMC11326614 | biostudies-literature
UnknownThe nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection.
Not available
S-EPMC12542944 | biostudies-literature
UnknownImportin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.
Not available
S-EPMC3270374 | biostudies-literature
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