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TranscriptomicsExpression profiling of Runx2 and CBFbeta siRNA treatment
Cells of MDA-MB-231 breast cancer cell-line were transfected with siRNA against Runx2, CBF-beta or non-specific siRNA used as control. Runx2 is a member of the Runx transcription factor family and possesses a Runt domain capable of binding to the consensus DNA sequence ACC(A/G)CA. This domain also i...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-MEXP-3230 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pooled embryonic humeri E14.5 from wild type and RUNX2-/- mutants detects novel skeletogenesis target genes
We used microarrays to identify genes differentially expressed between mouse RUNX2 -/- and wt embryonic humeri at stage E14.5 Experiment Overall Design: To minimize the effects of random biological variation, humeri from different preparations were pooled (approximately 75 wildtype and 60 Runx2-/- f...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4911 | biostudies-arrayexpress
GenomicsThe RUNX2 Cistrome in Osteoblasts: Characterization, Downregulation Following Differentiation and Relationship to Gene Expression [ChIP-Seq]
RUNX2 is a transcription factor that is first expressed in early osteoblast-lineage cells and represents a primary determinant of osteoblastogenesis. While numerous target genes are regulated by RUNX2, little is known of sites on the genome occupied by RUNX2 or of the gene networks that are control...
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-41920 | biostudies-arrayexpress
TranscriptomicsIdentification of putative target genes of the transcription factor RUNX2
We overexpress RUNX2 in ten human cell lines and identify genes that are affected by RUNX2 expression. These target genes provide a valuable resource into pathways regulated by RUNX2
ORGANISM(S): Homo sapiens 
2014-02-01 | E-MTAB-1875 | biostudies-arrayexpress
ProteomicsRUNX2 stimulates neoangiogenesis through the RUNT domain in melanoma
Transcription factors, by acting on gene expression can affect molecular pathways and can thereby induce malignant transformation. Among the transcription factors involved in cellular transformation, we recently highlighted the role of RUNX2 in melanoma cell migration and proliferation. In the prese...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012096 | Pride
Runx2 Neoangiogenesis Melanoma Proteomics 
ProteomicsPeptidylarginine deiminase 2 (PADI2) is a key regulator for osteoblast differentiation and bone formation through the maintenance of citrullination-mediated RUNX2 stability
Peptidylarginine deiminase (PADI) 2 catalyzes the posttranslational conversion of peptidyl-arginine to peptidyl-citrulline, a process called citrullination. However, the exact function of PADI2 in bone development and bone homeostasis remains unknown. In this study, we found that Padi2 deficiency le...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040179 | Pride
Citrullination Ptm Padi2 Lc-msms Runx2 
GenomicsGenome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion.
Runx2 is a metastatic transcription factor (TF) increasingly expressed during prostate cancer (PCa) progression. Using PCa cells conditionally expressing Runx2, we previously identified Runx2-regulated genes with known roles in epithelial-mesenchymal transition, invasiveness, angiogenesis, extracel...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-33889 | biostudies-arrayexpress
ProteomicsImportin-7 Promotes Tension-Induced Osteogenesis by Regulating RUNX2 Nuclear Translocation during Orthodontic Tooth Movement
Orthodontic tooth movement (OTM) is primarily driven by alveolar bone remodeling, wherein tension-induced osteogenesis plays a central role. Importin7 (IPO7) has been identified as a highly mechanoresponsive nuclear transport receptor (NTR). However, its role in regulating tension-induced osteogenes...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-06 | PXD061760 | Pride
Runx2 Mechanotransduction Ipo7 Tooth movement Nuclear translocation Alveolar bone remodeling 
TranscriptomicsOpposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value.
Analysis of reciprocal modulation of Runx2 and E2 signaling in BCA. Our objective was to investigate whether the interaction between estrogen and Runx2 signaling in breast cancer (BCa) could help refine an estrogen-responsive gene signature with improved prognostic value. MCF7/Rx2dox BCa cells condi...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-30597 | biostudies-arrayexpress
TranscriptomicsRunx2-mediated gene regulation is affected by its genomic occupancy
Osteogenesis is a highly regulated developmental process and continues during the turnover and repair of mature bone. Runx2, the master regulator of osteoblastogenesis, directs a transcription program essential for bone formation through both genetic and epigenetic mechanisms. While individual Runx2...
ORGANISM(S): Mus musculus 
2014-02-13 | E-GEOD-53982 | biostudies-arrayexpress
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