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MetabolomicsCD5L inhibits allergic airway inflammation by lysophosphatidylcholine-induced ILC2 apoptosis

Group 2 innate lymphoid cells (ILC2s) play key roles in allergic asthma development. We have previously revealed the inhibitory effect of CD5 antigen-like protein (CD5L) on allergic airway inflammation. Here, we analyzed the effect of CD5L on ILC2s.

2025-09-04 | MTBLS12937 | MetaboLights
MetabolomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis

Background: Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host...

2026-02-25 | MTBLS13930 | MetaboLights
MetabolomicsExercise-generated β-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway

OBJECTIVE: To explore the cardioprotective effects of exercise-derived β-aminoisobutyric (BAIBA) on cardiomyocyte apoptosis and energy metabolism in a rat model of heart failure (HF).

METHODS: In male Sprague-Dawley rats (8-week-old), myocardial infarction ...

2022-03-08 | MTBLS3927 | MetaboLights
ProteomicsProteomic Pathway Analysis Reveals Inflammation Increases Myeloid-Derived Suppressor Cell Resistance to Apoptosis
Myeloid derived suppressor cells (MDSC) accumulate in patients and animals with cancer where they mediate systemic immune suppression and obstruct immune based cancer therapies. To determine how inflammation enhances MDSC levels and activity we used mass spectrometry to identify proteins produced by...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-06-25 | MSV000082500 | MassIVE
TranscriptomicsSevere acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis
Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress respo...
ORGANISM(S): Chlorocebus aethiops 
2012-06-20 | E-GEOD-30589 | biostudies-arrayexpress
TranscriptomicsVitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcript...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-MEXP-3555 | biostudies-arrayexpress
ProteomicsEndothelial cell-derived apoptotic bodies modulate innate and adaptive immune responses during inflammation
Endothelial cells (ECs) act as gatekeepers and signalling hubs that coordinate communication between blood vessels and surrounding tissues by regulating vascular tone, immune responses and numerous other physiological processes. During vascular inflammation commonly associated with aging, atheroscle...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067178 | Pride
Human Lc-msms Endothelial Inflammation apoptosis 
ProteomicsFood-associated Lactiplantibacillus plantarum C9O4 reverts inflammation and apoptosis in intestinal epithelial cells: a proteomic insight
Nowadays, Western diets and lifestyle lead to an increasing occurrence of chronic gut inflammation, that represents an emerging health concern with still a lack of successful therapies. Fermented foods, and their associated Lactic Acid Bacteria, have recently regained popularity for their probiotic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042175 | Pride
Lpb. plantarum c9o4 Inflammation pathway Proteomics Intestinal cells 
TranscriptomicsPlasmid-free Chlamydia trachomatis elicit lowered inflammation, delayed apoptosis, and reduced chemoattractant expression in HeLa cells compared to plasmid-containing wild type
Chlamydia trachomatis serovariants are responsible for either Trachoma, the leading cause of infectious blindness or sexually transmitted disease, wherein the endocervix is the most frequently infected site in women. Disease caused by Chlamydia typically involves chronic inflammation and scarring. ...
ORGANISM(S): Homo sapiens 
2014-11-25 | E-GEOD-56168 | biostudies-arrayexpress
ProteomicsMitochondrial dysfunction caused by bacterial outer membranes vesicles activates intrinsic apoptosis and inflammation
Sensing of microbes activates the immune system, depending on functional mitochondria. However, pathogenic bacteria inhibit mitochondria activity by delivering toxins via outer membrane vesicles (OMVs). How innate immune cells respond to pathogenic microbes that target mitochondria remains unclear. ...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-30 | PXD018563 | Pride
Toxin Inflammation Pyroptosis Omv Macrophage Mitochondria Neisseria Bacteria Apoptosis Cell death 
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