Sort   by:  
 Page size 
ModelsPro-inflammatory Tumor Microenvironment in Acute Lymphoblastic Leukemia
Lineage fate decisions of hematopoietic cells depend on intrinsic factors and extrinsic signals provided by the bone marrow microenvironment, where they reside. Abnormalities in composition and function of hematopoietic niches have been proposed as key contributors of acute lymphoblastic leukemia (A...
4942 | Cell Collective
ProteomicsAdherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro-inflammatory tumor microenvironment in esophageal adenocarcinoma
Esophageal adenocarcinomas represent aggressive gastrointestinal malignancies, characterized by poor survival and variable responses to perioperative therapies. Our study identified a significant association between adherens junction (AJ) protein expression and treatment response to FLOT chemotherap...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD071328 | Pride
Esophageal adenocarcinoma Flot perioperative treatment Cell adhesion Tumor microenvironment 
TranscriptomicsExpression data from oxaliplatin-treated tumors from mice pre-treated or not with antibiotics cocktail
The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression and treatment of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tumor microenvironment. Here we show that disruption of the microbiot...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-51414 | biostudies-arrayexpress
ProteomicsGlioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
In order to further understand how glioma-derived IL-33 is orchestrating changes within the tumor microenvironment and based on the significant increase of anti-inflammatory mediators including a number of signaling molecules observed in IL-33+ tumors, we performed phospho-proteomic analysis using m...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-28 | PXD021100 | Pride
Phosphoproteomics Tumor associated macrophages/monocytes/microglia Human glioblastoma (gbm) Il-33 Glioma Tumor microenvironment (tme) 
UnknownDynamic roles of inflammasomes in inflammatory tumor microenvironment.
Not available
S-EPMC7940484 | biostudies-literature
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
ProteomicsTumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified tumor-associated macrophages (TAM) in the ascites as promoters of metastasis-associated processes l...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD016555 | Pride
Cancer Tumor-associated macrophages Ascites High-grade serous ovarian carcinoma Tumor microenvironment 
TranscriptomicsTranscription profiling of mouse CD11b cells purified from mouse spleen from umor-free and tumor-bearing mice
Active suppression of tumor-specific T lymphocytes can limit the immune-surveillance and immunotherapy efficacy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governi...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-5455 | biostudies-arrayexpress
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
TranscriptomicsTranscription profiling of bronchoalveolar lavage cells from AJ mice treated with urethane vs. controls
AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis of bronchoalveolar lavage cells from control or urethane treated mice. A unique macrophage expression signature in the lung tumor micro...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7258 | biostudies-arrayexpress
Sort   by:  
 Page size