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MetabolomicsMetabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great cl...

2022-01-13 | MTBLS239 | MetaboLights
TranscriptomicsExpression data from colonic biopsy samples of infliximab treated ulcerative colitis patients
A gene expression profiling sub-study was conducted in which colonic biopsy samples were collected for RNA extraction and hybridization to microarrays from 48 patients with UC who were participating in ACT 1, a placebo-controlled study of infliximab. Gene expression profiles from infliximab responde...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-23597 | biostudies-arrayexpress
TranscriptomicsMucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
Infliximab, an anti-TNF-alpha monoclonal antibody, is an effective treatment for ulcerative colitis (UC) with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-TNF-alpha is unknown. This study used colonic mucosal gene expression to pr...
ORGANISM(S): Homo sapiens 
2010-01-06 | E-GEOD-14580 | biostudies-arrayexpress
TranscriptomicsThe relationship between the gene expression profile in the synovium of RA patients at baseline and the clinical response to infliximab treatment
Background: Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-21537 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ulcerative colitis samples reveals a predictive response signature to infliximab treatment in ulcerative colitis
Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to respond to treatment. Consequently, about 40% of patients do not respond. This study analyzed mucosal gene expression from patients enrolled in ACT1 to provide a predi...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-12251 | biostudies-arrayexpress
TranscriptomicsMucosal expression profiling in patients with inflammatory bowel disease before and after first infliximab treatment
We used microarrays to identify mucosal gene signatures predictive of response to infliximab (IFX) in patients with inflammatory bowel disease (IBD) and to gain more insight into the pathogenesis of IBD. Keywords: drug response and treatment effect Mucosal biopsies were obtained at endoscopy in act...
ORGANISM(S): Homo sapiens 
2009-11-02 | E-GEOD-16879 | biostudies-arrayexpress
TranscriptomicsmRNA expression profile in peripheral blood cells of RA patients following treatment with an anti-TNFa mAb, infliximab
Objectives: We monitored the mRNA expression profiles of peripheral blood cells during treatment with a tumor necrosis factor-a inhibitor, infliximab, in patients with rheumatoid arthritis (RA). Using a DNA microarray analysis, we demonstrated a unique set of genes, with distinct baseline and post-t...
ORGANISM(S): Homo sapiens 
2007-10-09 | E-GEOD-8350 | biostudies-arrayexpress
TranscriptomicsSynovial biopsies from RA and PsA patients and skin biopsies from Psoriasis patients under Infliximab treatment
Object: to understand Infliximab treatment effect on the molecular expression of tissue at disease site 4mm punch biopsies were performed on involved and uninvolved skin at baseline in 5 Ps patients. A repeat biopsy was performed at week 2 after IFX therapy at a site adjacent to the baseline biopsy ...
ORGANISM(S): Homo sapiens 
2014-10-29 | E-GEOD-57376 | biostudies-arrayexpress
TranscriptomicsDistinct, non-overlapping gene panels of peripheral blood gene expression predict response to infliximab therapy in rheumatoid arthritis and Crohn's disease
We used microarrays to identify markers predicting responder status in infliximab treatment in 19 rheumatoid arthritis and 20 Crohn's disease patients at week 0 and week 2 of treatment. Peripheral blood samples were obtained at week 0 and week 2 of inxliximab treatment and global gene expression pro...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-42296 | biostudies-arrayexpress
ProteomicsHLA-DR MAPPs Assay in moDCs From 8 Donors Loaded With Infliximab
MHC-associated peptide proteomics (MAPPs) enables direct identification of peptides naturally processed and presented by APCs, providing experimental evidence for antigen processing and HLA class II presentation. In this dataset published in PMID: 41085630, an HLA-DR–focused MAPPs workflow was used ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD074155 | Pride
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