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MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
MetabolomicsMicrobial metabolites calibrate innate immunity upon systemic viral infection

Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...

2026-08-01 | MTBLS7382 | MetaboLights
MetabolomicsAssociation between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease

Chagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory resp...

2024-01-11 | MTBLS8390 | MetaboLights
MetabolomicsThe gut microbiota contributes to changes in the host immune response induced by Trichinella spiralis
The gut microbiota plays an important role in parasite-host interactions and the induction of immune defense responses. Trichinella spiralis is an important zoonotic parasite that can directly or indirectly interact with the host in the gut. Changes in the gut microbiota following infection with T. ...
2023-08-07 | MTBLS7603 | MetaboLights
MetabolomicsGut microflora alleviate immune response during E.coli-induced bladder cystits via AhR/MANF activation

In recent years, with the deepening of research on intestinal microbiota, we found intestinal microbiota plays an important role in host immune regulation and barrier maintenance through cross-talk between the microbiota and the host. New evidence suggests that disruption of the fragile balance w...

2023-07-11 | MTBLS5572 | MetaboLights
MetabolomicsChlorogenic acid alters ileal microbiota and metabolites in broilers under immune stress

Immune stress in broilers can cause severe economic losses, chlorogenic acid is an effective plant extract for alleviating immune stress. This study investigates the effect of chlorogenic acid on the intestinal microbiota and metabolites of broilers under immune stress. 312 broilers were randomly...

2025-06-09 | MTBLS11790 | MetaboLights
TranscriptomicsHuman CA2 ES cells undergoing stepwise differentiation to airway epithelium and challenged with TNFa and LPS
This study examines the innate immune response of human pluripotent stem cell derived airway epithelium. Immune challenge was performed with TNF-alpha or bacterial lipopolysaccharide (LPS) Airway epithelium differentiated from the ES line CA2 was compared to paired differentiated cells stimulated wi...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-59472 | biostudies-arrayexpress
ProteomicsTranscriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
ORGANISM(S): Olavius Algarvensis (ncbitaxon:188229) 
2016-02-12 | MSV000079512 | MassIVE
TranscriptomicsPlatelet Activating Factor Receptor and Innate Immunity
This data series contains spotted oligo microarray data from 10 different experiments using Agilent Rat v2 microarrays. This data is being made public in support of Fillon S et al. Journal of Immunology, (2006). Proinflammatory bacterial components are at least partially responsible for causing the ...
ORGANISM(S): Rattus norvegicus 
2010-07-01 | E-GEOD-5545 | biostudies-arrayexpress
Transcriptomicshyperlipidemia impaired innate response
To explore the effect of hyperlipidemia on macrophages' innate immune response to Porphyromonas gingivalis invasion 12 samples, 3 replicates in 4 groups, with cells from hyperlipidemic ApoE deficient mice and nonhyperlipidemic C57BL/6 mice stimulate with or without P.gingivalis(Pg)
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-42061 | biostudies-arrayexpress
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