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TranscriptomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RNA-seq]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61329 | biostudies-arrayexpress
GenomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RRBS]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61330 | biostudies-arrayexpress
MetabolomicsFlavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves
Ginkgo leaves are always resources for flavonoids pharmaceutical industry. However, the effect of the elevation and tree age changes on flavonoid biosynthesis have not been detailly explored in Ginkgo leaves. In addition, whether these environmental pressures have similar effects on the biosynthesis...
2020-12-14 | MTBLS962 | MetaboLights
UnknownA genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor.
Not available
S-EPMC8500687 | biostudies-literature
ProteomicsPlasma proteome of mild cognitive impairment
Multiple Affinity Removal Spin Cartridge Human 14 kit (Agilent) was used to remove 14 major proteins from plasma. Samples were denatured with an equivalent volume of trifluoroethanol and reduced with dithiothreitol. Free cysteine residues were alkylated with iodoacetamide. Samples were incubated wi...
ORGANISM(S): Homo Sapiens (human) 
2022-05-11 | PXD025937 | JPOST Repository
ProteomicsQuantitative plasma proteome of mild cognitive impairment
Multiple Affinity Removal Spin Cartridge Human 14 kit (Agilent) was used to remove 14 major proteins from plasma. Samples were denatured with an equivalent volume of trifluoroethanol and reduced with dithiothreitol. Free cysteine residues were alkylated with iodoacetamide. Samples were incubated wi...
ORGANISM(S): Homo Sapiens (human) 
2022-05-11 | PXD025945 | JPOST Repository
UnknownG proteins of the G<sub>12</sub> family expressed by POMC neurons regulate key metabolic functions.
Not available
S-EPMC12248387 | biostudies-literature
UnknownStructural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Not available
S-EPMC9870890 | biostudies-literature
TranscriptomicsLoss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor/TRAF6 signaling
TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient gene in del(5q) Myelodysplastic syndrome (MDS). Hematopoietic-specific deletion of Tifab results in progressive bone marrow (BM) and blood defects, including skewed hematopoietic stem/progenitor cells (HSPC) pr...
ORGANISM(S): Mus musculus 
2015-09-12 | E-GEOD-72936 | biostudies-arrayexpress
UnknownFunction and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.
Not available
S-EPMC10085991 | biostudies-literature
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