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MetabolomicsMetabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to 10 individual essential amino acid (EAA) avai...

2022-05-24 | MTBLS3963 | MetaboLights
TranscriptomicsTranscription profiling of rat insulinoma-beta (INS-1E) cells exposed to the cytokines IL-1-beta and IFN-gamma for six different lengths of time and with or without the inducible NO synthase blocker NMA
Locally released cytokines contribute to beta cell dysfunction and apoptosis in Type 1 diabetes. In vitro exposure of insulin producing INS-1E cells to the cytokines interleukin (IL)-1beta + interferon (IFN) gamma leads to a significant increase in apoptosis. To characterize the genetic networks im...
ORGANISM(S): Rattus norvegicus 
2006-06-14 | E-CBIL-10 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of clonal INS-1 832/13 beta-cells
This experiment aimed to measure gene expression in glucose-responsive beta-cells. RNA was extracted using RNeasy Mini kit. Quantity and quality of extracted RNA were assessed by the NanoDrop spectrophotometer ND-1000 and Experion RNA StdSens Analysis Kit, respectively. Background correction, normal...
ORGANISM(S): Rattus norvegicus 
2015-01-30 | E-MTAB-3232 | biostudies-arrayexpress
TranscriptomicsEffect on JNK knock-down in INS-1 insulin-producing cells
Investigates the effect of shRNA knock-down of JNK1, JNK2, JNK3 in INS-1 insulin producing cells compared to untransfected INS-1 cells before and after treatment with IL-1beta for 45 min and 6 h.
ORGANISM(S): Rattus norvegicus 
2014-12-30 | E-MTAB-3146 | biostudies-arrayexpress
ProteomicsCellular concentrations of Protein Kinase D1 in HEK293T and INS-1 cells
Protein kinase D1 (PRKD1, also referred to as PKD1), has been proposed to undergo concentration dependent dimerization in vitro. To test whether the cellular concentration of PKD1 is in the range of the dissociation constant obtained, the expression level of PKD1 was investigated by PRM. To this end...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2019-08-19 | PXD013232 | Pride
Pkd1 Ins-1 Protein kinase d Hek293t 
TranscriptomicsTranscription profiling of rat insulinoma line INS-1 to identify targets of HNF1b mutants in INS-1
A rat insulinoma cell line (INS-1) was generated that contains a FRT site for FLP recombinase mediated site specific integration of specific genes. In addition, the line contains the tetracycline repressor allowing tetracycline (tet) induction of the introduced gene. By comparing the gene expression...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1590 | biostudies-arrayexpress
GenomicsTranscriptome analysis of mir-1-deficient and ins-1-deficient Caenorhabditis elegans
Transcriptome analysis of mir-1-deficient and ins-1-deficient Caenorhabditis elegans
PRJNA529590 | ENA
TranscriptomicsTranscription profiling of Rattus norvegicus pancreatic beta cell line expressing HNF1b, HNF4a2 or HNF6
This SuperSeries is composed of the following subset Series:; GSE1589: Targets of HNF1b, HNF4a2 and HNF6 in INS-1 cells; GSE1590: Targets of HNF1b mutants in INS-1; GSE1591: INS-1 cell lines (FLP-In T-REx) Experiment Overall Design: Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-6428 | biostudies-arrayexpress
TranscriptomicsGene expression changes in response to doxycyline-induced expression of proinsulin (C96Y)-GFP in an INS-1 insulinoma cell line
A doxycyline-inducible INS-1 insulinoma cell line expressing proinsulin (C96Y)-GFP was engineered. Addition of doxycyline causes the production of the proinsulin (C96Y)-GFP, which is retained in the endoplasmic reticulum. This study analyzes the gene expression changes that occur after doxycyline-in...
ORGANISM(S): Rattus norvegicus 
2010-07-29 | E-GEOD-22537 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat insulinoma INS-1 cell lines (FLP-In T-REx)
Four rat insulinoma cell lines (INS-1) were generated that contain a FRT site for FLP recombinase mediated site specific integration of specific genes. In addition, the cell lines contain the tetracycline repressor allowing tetracycline (tet) induction of the introduced gene. By comparing the gene e...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1591 | biostudies-arrayexpress
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