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ProteomicsPhosphoprotoemics analysis of FAO cells stimulated with insulin
FAO cells, rat hepatoma cells, were stimulated with 1 nM insulin and collected at seven time points for ~60 minutes. Ion metal affinity chromatography (IMAC) was performed to enrich the phosphopeptides. As we used two sets of 4-plex iTRAQ to quantify the peptides from seven samples, we set the inter...
ORGANISM(S): Rattus Rattus (black Rat) 
2018-11-30 | PXD005900 | JPOST Repository
TranscriptomicsFunction-based discovery of significant transcriptional temporal patterns in insulin-stimulated muscle cells
Background: Insulin's effect on protein synthesis (translation of transcripts) and post-translational modifications, especially those involving reversible modifications such as phosphorylation of various signaling proteins, are extensively studied. On the other hand, insulin's effect on the transcri...
ORGANISM(S): Rattus norvegicus 
2012-05-02 | E-GEOD-28997 | biostudies-arrayexpress
GenomicsDisorders of growth and insulin action
Illumina paired-end sequencing of whole- exome pulldown DNA from Severe Insulin Resistant patients.
EGAS00001000041 | EGA
TranscriptomicsMechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing?
Transcriptional profiling of insulin exposed H4IIE cells at different time points (6h-24h) to 100 nM insulin, with untreated solvent control cells (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its developme...
ORGANISM(S): Rattus norvegicus 
2012-06-17 | E-GEOD-35697 | biostudies-arrayexpress
TranscriptomicsSkeletal muscle and insulin regulated genes
Insulin action in target tissues involved precise regulation of gene expression. To define the set of insulin-regulated genes in human skeletal muscle, we analyzed the global changes in mRNA levels during a 3-h hyperinsulinemic euglycemic clamp in vastus lateralis muscle of six healthy subjects. Usi...
ORGANISM(S): Homo sapiens 
2005-12-20 | E-GEOD-3881 | biostudies-arrayexpress
TranscriptomicsPhenothiazine Neuroleptics Signal To The Human Insulin Promoter As Revealed By A Novel Human b-Cell Line Based Screen
(original Title) Phenothiazine Neuroleptics Signal To The Human Insulin Promoter As Revealed By A Novel Human b-Cell Line Based High-Throughput Screen. To address the current deficiency in human beta-cell models, we have developed a cell line from human islets in which the expression of insulin and...
ORGANISM(S): Homo sapiens 
2010-08-06 | E-GEOD-18821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse finally differentiated 3T3-L1 adipocytes treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours
Finally differentiated 3T3-L1 adipocytes are treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours to understand insulin and metformin(an anti-diabetic drug commonly applied for Non-Insulin Dependent Diabetes Mellitus)action in adipose tissues.
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-8 | biostudies-arrayexpress
TranscriptomicsAdipose Rab10 Knockout Causes Insulin Resistance through Impaired Glucose Uptake
Insulin action in adipocytes affects whole-body insulin sensitivity. Studies of adipose-specific Glut4 knockout mice have established that adipose Glut4 contributes to the control of systemic glucose homeostasis. Presumably, this reflects a role for Glut4-mediated glucose transport in the regulation...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-70123 | biostudies-arrayexpress
TranscriptomicsInsulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men
Rationale: Physical inactivity is a risk factor for insulin resistance. We examined the effect of nine days of bed rest on basal and insulin stimulated expression of genes potentially involved in insulin action by applying hypothesis-generating microarray in parallel with candidate gene real-time PC...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-24215 | biostudies-arrayexpress
no omics definedTranscription profiling of mouse skeletal muscle in streptozotocin diabetes with or without insulin treatment
Metabolic abnormalities underlying diabetes are primarily the result of the lack of adequate insulin action and the associated changes in protein phosphorylation and gene expression. Affymetrix oligonucleotide microarrays were used to study the changes in the transcriptional program of mouse skeleta...
ORGANISM(S): Mus musculus 
2007-04-05 | E-CBIL-25 | biostudies-arrayexpress
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