Insulin exocytosis

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Paul & Ellen Lacy Professor of Pathology & Immunology Division of Immunobiology Washington University in St. Louis St. Louis, MO 63110 USA (1)
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Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis Department of Cell Biology & Physiology, Washington University, St. Louis (1)
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Charité Universitätsmedizin, Department of Biochemistry, 10117 Berlin, Germany The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK Max Planck Institute for Molecular Genetics, Berlin, Germany (1)

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Transcription profiling of wild type and Foxa2 knock out mouse mature beta cells

The winged helix transcription factor Foxa2 regulates Pdx1 gene expression and fetal endocrine pancreas development. We show here by inducible gene ablation that Foxa2 inactivation in mature beta-cells induces hyperinsulinemic hypoglycemia in Foxa2loxP/loxP, Pdx1-CreERT2 adult mice. Mutant beta-cell...

ORGANISM(S): Mus musculus

2007-09-22 | E-CBIL-39 | biostudies-arrayexpress

Nova1 is a master regulator of alternative splicing in pancreatic beta cells

Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human genes but its role in the regulation of pancreatic beta cells, the producers of insulin, remains unknown. Our recently published data indicated that the M-bM-^@M-^\neuron spe...

ORGANISM(S): Rattus norvegicus

2014-10-01 | E-GEOD-59633 | biostudies-arrayexpress

Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.

Not available

S-EPMC4413049 | biostudies-literature

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

PRJNA472771 | ENA

Insulin Granule and Secreted Peptidome

Insulin peptidome, for dense core granules, crinosomes and secretome, was characterized by nLC-MS/MS.

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2018-07-23 | PXD009919 | Pride