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MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
TranscriptomicsTranscription profiling of preadipocytes of wild type and IRS-1,IRS-2, IRS-3, IRS-4 knock out mice to reveal role of insulin receptor substrates and necdin
Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to ...
ORGANISM(S): Mus musculus 
2007-08-04 | E-GEOD-2556 | biostudies-arrayexpress
TranscriptomicsResponse of peripheral blood mononuclear cells from 20 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (IGRP, PPI) derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 20 healthy donors and 15 pat...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72377 | biostudies-arrayexpress
ProteomicsThe pancreatic islet MHC-II peptidome identifies key features of autoimmune peptides
The nature of autoantigens that trigger autoimmune diseases has been much discussed but direct biochemical identification is lacking for most. Addressing this question demands unbiased examination of the self-peptides displayed by a defined autoimmune MHC-II molecule. We have examined the immunopept...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-12 | PXD015408 | Pride
Hybrid insulin peptides Pln Mhc-ii peptidome Nod mouse Islets Spleen 
TranscriptomicsResponse of peripheral blood mononuclear cells from 15 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (GAD65, IGRP, PPI, ZnT8) and influenza virus M derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 15 healthy donors and 15 pat...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72376 | biostudies-arrayexpress
TranscriptomicsMOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of addi...
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-65068 | biostudies-arrayexpress
ProteomicsAdipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
Extracellular vesicles are membranous nanoparticles that convey signaling between cells, tissues and organs. By applying fluorescence tracing and SILAC-labeling paired with (phospho)proteomics, we identified the transfer of functional insulinotropic protein cargo via adipocyte-derived extracellular ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-03-11 | PXD037809 | Pride
Proteomics Insulin secretion Silac Extracellular vesicles Adipose tissue Phosphoproteomics Lc-ms/ms 
GenomicsB cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
PRJNA1186168 | ENA
GenomicsB cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
PRJNA1185752 | ENA
GenomicsB cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
PRJNA1186167 | ENA
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