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TranscriptomicsInsulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma
Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; c...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-9600 | biostudies-arrayexpress
GenomicsGenome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells
The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity. We report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1 (SUMO-1) ...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-23792 | biostudies-arrayexpress
TranscriptomicsNeurotrophic factors and their receptors are altered by the mere partial IGF-1 deficiency
Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair, and survival of neurons; playing a role in the maintenance of the synaptic unions, dendrites and axons; also, being crucial for peripheral nervous system development and regulating pl...
ORGANISM(S): Mus musculus 
2018-12-29 | E-MTAB-7508 | biostudies-arrayexpress
GenomicsThe effect of insulin-like growth factor 1 and insulin on neutrophil polarization
The effect of insulin-like growth factor 1 and insulin on neutrophil polarization
PRJNA814614 | ENA
TranscriptomicsPlatelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor
Platelets contain abundant miRNAs, however, the biogenesis pathway of miRNAs in anucleate platelets is unclear. Platelet-rich plasma was diluted in washing buffer and the platelet suspension was centrifuged to isolated pure platelets.Finally, platelets were recovered in suspension buffer at the conc...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-51453 | biostudies-arrayexpress
ModelsInsulin-like growth factor signaling - PLM_62, version 1, SUBMITTED
Insulin-like growth factor signaling - PLM_62, version 1, SUBMITTED
2019-01-10 | 468 | FAIRDOMHub
TranscriptomicsTranscription profiling of mouse primary visual cortext from animals treated with monocular deprivation (MD), dark rearing and controls reveals binding protein of Insulin-like Growth Factor 1 is highly upregulated after MD
Two key paradigms for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD).,Combining DNA microarray analysis with computational appr...
ORGANISM(S): Mus musculus 
2007-07-07 | E-GEOD-4537 | biostudies-arrayexpress
ProteomicsY-daf2-FF
Young, daf2 wild type, fully fed group
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2013-12-31 | PAe005606 | PeptideAtlas
ProteomicsO-daf2-DR
Old, daf2 wild type, dietary restriction group
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2013-12-31 | PAe005589 | PeptideAtlas
ProteomicsO-mut-FF
Old, daf2 mutants, fully fed group
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2013-12-31 | PAe005575 | PeptideAtlas
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