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ProteomicsImproving quantitative glycoproteomics by systematic evaluation of different glycopeptide enrichment, quantification, and mass spectrometry strategies
In this study, we conducted a systematic investigation into a glycoproteomic workflow. Firstly, Label-free and TMT labeling strategies were utilized for intact N-glycopeptide quantification. A total of 2,924 unique intact N-glycopeptides can be quantified after being labeled using TMT approach. Comp...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-07 | PXD054874 | Pride
Glycoproteomics Intact glycopeptide Identification Quantification 
ProteomicsAn automated intact glycopeptide enrichment method for serum site-specific N-glycoproteomic analysis
We developed an automated glycopeptide enrichment method for the analysis of serum site-specific N-glycoproteome. This automated method allowed for processing one sample within 20 min. It showed higher enrichment specificity, more intact glycopeptide identifications, and better quantitative reproduc...
ORGANISM(S): Homo Sapiens (human) 
2021-04-06 | PXD025151 | JPOST Repository
ProteomicsN-Glycoproteomic analysis reveals novel mechanism and clinical relevance in Colorectal Cancer
Glycosylation is largely involved in development and progression of cancer and provides multiple novel targets for diagnostic application and therapeutic strategies. Recent advances in methods for enrichment and mass spectrometric interpreting of intact N-glycoprotein contribute to large-scale clini...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD055957 | Pride
N-glycoproteomic  colorectal cancer  mechanism  cancer therapies 
ProteomicsAutoGP 2: an improved fully automated high-throughput system for simultaneously enriching and separating intact glycopeptides
An improved fully automated high-throughput system, named as AutoGP 2, for simultaneously enriching and separating intact glycopeptides has been developed in this study by introducing a second 10-port valve (valve 2) to the previously developed AutoGP system with only a 10-port valve (valve 1). Spec...
ORGANISM(S): Mus Musculus 
PXD069435 |
ProteomicsOn-tissue spatially-resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape
Here we present an approach to identify N-linked glycoproteins and deduce their spatial localization using a combination of MALDI N-glycan MSI and spatially-resolved glycoproteomics. We subjected glioma biopsies to on-tissue PNGaseF digestion and MALDI-MSI and found that the glycan HexNAc4-Hex5-NeuA...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-05-04 | PXD025537 | Pride
Glioblastoma Spatially resolved glycoproteomics Glycoproteomics Glycan imaging Haptoglobin Sialic acid Spatially resolved glycoproteomicsglycan imaging Maldi-msi Hypersialylation 
ProteomicsIntact N-glycopeptides and proteomics from HCC tissue tumors with low and high AFP concentrations
Hepatocellular carcinoma (HCC) is still one of the malignant tumors with high morbidity and mortality in China and worldwide. Although AFP have been widely used as important biomarkers for HCC diagnosis and evaluation, the AFP level has a huge variation among HCC patient populations. Understanding t...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016406 | Pride
Proteomics Intact glycopeptide Mass spectrometry Hepatocellular carcinoma 
UnknownComprehensive Glycoproteomic Analysis of Chinese Hamster Ovary Cells.
Not available
S-EPMC6440468 | biostudies-literature
ProteomicsN-Glycoproteomic Analysis of Botryococcus Braunii
We have performed an N-glycoproteomic analysis of the green microalgae Botryococcus braunii, a promising candidate for the production of biofuels, accumulating considerable amounts of hydrocarbon oils. Thereby, three different strains have been compared: Showa (Race B), AC761 (Race B) and CCALA778 (...
ORGANISM(S): Botryococcus braunii 
2017-08-08 | PXD005708 | Pride
Algae Botryococcus braunii N-glycosylation 
ProteomicsComparative glycoproteomic profiling of human body fluid between healthy controls and patients with papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer among women worldwide. It is confirmed mainly by fine-needle aspiration biopsy (FNAB), an invasive diagnostic method. The key proteins responsible for thyroid hormone biosynthesis are glycosylated. Changes in site-specific g...
ORGANISM(S): Homo sapiens (Human) 
2019-12-09 | PXD015360 | Pride
Biomarker  mass spectrometry  site-specific n-glycopeptide  thyroid cancer 
UnknownTissue-specific and sex-biased glycoproteomic landscape of Schistosoma mansoni.
Not available
S-EPMC12909830 | biostudies-literature
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