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ProteomicsCancer burden is controlled by mural cell- β3-integrin regulated crosstalk with tumor cells
Phosphoproteomics analysis were performed in WT and β3-integrin-null pericytes. On the other hand, phosphoproteomics experiments were done in B16F0 melanoma cells treated for 24 hours with conditioned medium from WT and β3-integrin-null pericytes.
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD014513 | Pride
Paracrine Β3-integrin Mural-cell 
ProteomicsThe tongue squamous carcinoma cell line Cal27 primarily employs integrin α6β4-containing type II hemidesmosomes for adhesion which contribute to anticancer drug sensitivity
Integrins are heterodimeric cell surface glycoproteins used by cells to bind to the extracellular matrix (ECM) and regulate tumor cell proliferation, migration and survival. A causative relationship between integrin expression and resistance to anticancer drugs has been demonstrated in different tum...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028810 | Pride
Integrin crosstalk Hemidesmosome Laminin-332 Keratins 5/14 Adhesome Integrin αvβ3 Integrin α6β4 Anticancer drug sensitivity 
UnknownMechanisms of talin-dependent integrin signaling and crosstalk.
Not available
S-EPMC3877210 | biostudies-literature
UnknownN-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity.
Not available
S-EPMC11479646 | biostudies-literature
UnknownMultivalent DNA Origami Enables Single-Molecule Dissection of Integrin αvβ6-Receptor Tyrosine Kinase Crosstalk in Cancer Biology.
Not available
S-EPMC12424295 | biostudies-literature
UnknownTargeting the Extra-Cellular Matrix-Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors.
Not available
S-EPMC7387567 | biostudies-literature
UnknownThe Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
Not available
S-EPMC4409120 | biostudies-literature
UnknownPathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.
Not available
S-EPMC4832077 | biostudies-literature
GenomicsControl of basal-type prostate cancers with a bispecific integrin α5β1/αv antibody
Control of basal-type prostate cancers with a bispecific integrin α5β1/αv antibody
PRJNA1237843 | ENA
UnknownThrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells.
Not available
S-EPMC7789630 | biostudies-literature
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