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MetabolomicsAn Atlas of Inter-Organ Metabolite Trafficking in Health and Atherogenic Conditions

Mammalian organs continuously exchange circulating metabolites for organismal health and survival. However, the landscape of this fundamental process and its perturbation by diet and disease is unknown. Using arteriovenous metabolomics, tissue transcriptomics, hormone arrays and multiple metaboli...

2025-05-12 | MTBLS10288 | MetaboLights
ProteomicsHepatic steatosis contributes to the development of muscle atrophy via inter-organ crosstalk
Individuals with hepatic steatosis often display several metabolic abnormalities including insulin resistance and muscle atrophy. Previously, we found that hepatic steatosis results in an altered hepatokine secretion profile, thereby inducing skeletal muscle insulin resistance via inter-organ crosst...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027332 | Pride
Insulin resistance Metabolism Muscle atrophy Liver steatosis Nafld Inter-organ crosstalk 
UnknownThe dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk.
Not available
S-EPMC11605122 | biostudies-literature
UnknownHepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk.
Not available
S-EPMC8542925 | biostudies-literature
UnknownLatent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach.
Not available
S-EPMC10713585 | biostudies-literature
UnknownFat-to-heart crosstalk in health and disease.
Not available
S-EPMC10079901 | biostudies-literature
UnknownModulation of inter-organ signalling in obese mice by spontaneous physical activity during mammary cancer development.
Not available
S-EPMC7260359 | biostudies-literature
UnknownLiver-bone organoids reveal senescence-driven interorgan crosstalk.
Not available
S-EPMC12444486 | biostudies-literature
UnknownCrosstalk Between Skeletal Muscle and Proximal Connective Tissues in Lipid Dysregulation in Obesity and Type 2 Diabetes.
Not available
S-EPMC12471726 | biostudies-literature
UnknownSystemic Lonp1 Haploinsufficiency Mitigates Cardiac Mitochondrial Dysfunction Induced by Cardiomyocyte-Specific Lonp1 Haploinsufficiency via Potential Inter-Organ Crosstalk
Not available
S-EPMC12384522 | biostudies-literature
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