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MetabolomicsClostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation

The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection re...

2023-05-30 | MTBLS4590 | MetaboLights
TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies have considerable drawbacks and fail to replace the normal disc in facilitating spinal movements a...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-70362 | biostudies-arrayexpress
TranscriptomicsRole of CDK8 in interferon-gamma-induced gene expression
Gene regulation by cytokine-activated STAT transcription factors requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation was reported to occur upon promoter binding by an unknown kinase. Here we show that the Mediator CDK8 module phosphorylates S7...
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-40728 | biostudies-arrayexpress
MetabolomicsA Multi-omics Longitudinal Study Reveals Alteration of the Leukocyte Activation Pathway in COVID-19 Patients
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due to excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures associated with the elevated im...
2022-01-18 | MTBLS2469 | MetaboLights
ProteomicsUBE2O targets a novel substrate IFIT3 for ubiquitination and degradation, impeding the interferon pathway activation and interferon sensitization in hepatocellular carcinoma
Abstract Rationale: Interferon (IFN) plays a key role in immunotherapy by acting through interferon-stimulated genes. Interferon resistance limits its efficacy. Ubiquitination modification of key proteins is a popular research direction in hepatocellular carcinoma (HCC), and it is also one of the im...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039704 | Pride
Ube2o Interferon pathway Hepatocellular carcinoma Ifit3 Interferon sensitivity 
ProteomicsUBE2O targets a novel substrate IFIT3 for ubiquitination and degradation, impeding the interferon pathway activation and interferon sensitization in hepatocellular carcinoma
Abstract Rationale: Interferon (IFN) plays a key role in immunotherapy by acting through interferon-stimulated genes. Interferon resistance limits its efficacy. Ubiquitination modification of key proteins is a popular research direction in hepatocellular carcinoma (HCC), and it is also one of the im...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039711 | Pride
Ube2o Interferon pathway Hepatocellular carcinoma Ifit3 Interferon sensitivity 
TranscriptomicsInterferon-stimulated gene expression in STAT1 knockout cells
STAT1 plays a cental role in the induction of interferon-stimulated genes, but interferon alpha can activate a STAT1-independent pathway that leads to gene expression. We performed microarray analysis to examine whether like interferon alpha, interferon lambda, a newly discovered interferon, can ind...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-84693 | biostudies-arrayexpress
TranscriptomicsTimecourse of Interferon-Gamma Treatment of Bone Marrow-Derived Macrophages (BMDMs)
The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma (IFN-g)) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the p...
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-42504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Pias1 null cells in response to IFN treatments to study the effect of PIAS1 on interferon (IFN) signaling pathway
Microarray analysis was designed to study the effect of PIAS1 on interferon (IFN) signaling pathway by comparing the gene activation profiles of wild type and Pias1 null cells in response to IFN treatments. Microarray analysis was performed essentially following the manufacturer's instructions (Affy...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1552 | biostudies-arrayexpress
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