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The pre and postnatal environment can affect both an individual’s risk of adult onset metabolic disease and that of subsequent generations. Although animal models and epidemiological data implicate epigenetic inheritance, little is known of the mechanisms involved. In a robust intergenerational mo...
ORGANISM(S): Mus musculus 
Intergenerational inheritance of trained immunity and heterologous resistance to infections (ATAC-seq)
Intergenerational inheritance of trained immunity and heterologous resistance to infections (RRBS - DNA methylation)
Intergenerational inheritance of trained immunity and heterologous resistance to infections (RNA-seq)
Mixed patterns of intergenerational DNA methylation inheritance in Acropora
Increasing evidences indicate diet-induced metabolic disorder could be paternally inherited, but the exact sperm epigenetic carrier remains unclear. Here, in a paternal high-fat diet (HFD) mouse model, we revealed that a highly enriched subset of sperm small RNAs (30-34 nt) that derived from the 5â€...
ORGANISM(S): Mus musculus 
Intergenerational inheritance (Inter-I) of phenotypic characteristics has been demonstrated in plants and invertebrates, with epigenetic modifications playing a role in the inheritance of a variety of features such as appearance1, adaptation to stress, or resistance to infections. Here we provide ev...
ORGANISM(S): Mus musculus 
2021-08-23 | GSE130325 | GEO
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