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TranscriptomicsBulk RNA sequencing of coding RNA from splenic dendritic cells isolated from interleukin-2 complex-treated and untreated mice
We discovered that interleukin-2 expands mouse dendritic cells in vivo. This RNA-seq experiment intended to identify the transcriptional changes in mouse conventional dendritic cells after interleukin-2 complex treatment and to possibly identify activated signaling pathways.
ORGANISM(S): Mus musculus 
2020-09-16 | E-MTAB-8991 | biostudies-arrayexpress
GenomicsRegulating Interleukin-2 activity with engineered receptor signaling clamps
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. Previously, we engineered an IL-2 “superkine” (H9) with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
TranscriptomicsMechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2Rβ and the common cytokine receptor γ-chain, γc, We find that in the IL-15/IL-15Rα/IL-2Rβ/γc quaternary complex structure, IL-15 heterodimerizes IL-2Rβ and γc identically to the IL-2/IL-2Rα/IL...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-40350 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A673 Ewing family tumor cell line transfected with interleukin-2 expression vector
Response of A673-cells to transfection with interleukin 2 (IL-2). Ewing family tumor (EFT) cell line A673 was transfected with an expression vector for IL-2 (cell line SBVGA1) or empty control vector (cell line SBVGA3). Cells were harvested at 3 different time points and processed for DNA-microarray...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1823 | biostudies-arrayexpress
ModelsFallon2000 - Interleukin-2 dynamics
This a model from the article: Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response. Fallon EM, Lauffenburger DA. Biotechnol Prog 2000 Sep-Oct;16(5):905-16 11...
2024-09-02 | BIOMD0000000665 | BioModels
ModelsBanerjee2008 - Immunotherapy with interleukin-2: A study based on mathematical modeling
IMMUNOTHERAPY WITH INTERLEUKIN-2: A STUDY BASED ON MATHEMATICAL MODELING S ANDIP B ANERJEE Indian Institute of Technology and Science Rooorkee (IITR) Roorkee 247667, Uttarakhand, India e-mail: sandofma@iitr.ernet.in The role of interleukin-2 (IL-2) in tumor dynamics is illustrated through mathemat...
2020-01-13 | MODEL2001130001 | BioModels
ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080850 | MassIVE
ProteomicsInterleukin-2 shapes the cytotoxic T cell proteome and immune-environment sensing
Interleukin-2 (IL-2) and Janus kinases (JAKs) regulate transcriptional programs and protein synthesis to control the differentiation of effector CD8+ cytotoxic T cells (CTL). Using high-resolution mass spectrometry, we have generated an in-depth characterisation of how IL-2 and JAKs configure the CT...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-17 | PXD008112 | Pride
Proteomics Jak1 Il-2 Interleukin-2 Jak3 Lymphocytes 
ProteomicsChanges in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes
Interleukin-2 (IL-2) stimulation results in T-cell growth as a consequence of activation of highly sophisticated and fine-tuned signaling pathways. Despite lacking intrinsic enzymatic activity, scaffold proteins such as Gab2, play a pivotal role in IL-2-triggered signal transduction integrating, div...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080707 | MassIVE
GenomicsCytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation
T helper (Th) cells control host defense to pathogens. IL 12R expression is required for Th1, IL-4RM-NM-1 for Th2, and IL-6RM-NM-1/gp130 for Th17 differentiation to allow responsiveness to IL-12, IL-4, and IL-6, respectively. IL-2 via STAT5 controls Th2 differentiation by regulating the Th2 cytokine...
ORGANISM(S): Homo sapiens 
2011-04-24 | E-GEOD-27158 | biostudies-arrayexpress
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