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ProteomicsSuccination analysis of JAK1 and IKK2 using targeted MS/MS analysis
Using Affinity Purification in tandem to targeted LC-MS/MS analysis, we identified possible succination sites of JAK1 and IKK2 proteins follwoing DMF treatement. We looked for the specific 2-Dimethylsuccinyl modifications of Cysteins residues.
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD024441 | Pride
Cysteins succination Affinity mass spectrometry Jak Dmf Ikkb 
ProteomicsSelective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine
The JAK family of non-receptor tyrosine kinases includes four subtypes (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction downstream of diverse cytokine receptors. JAK inhibitors have emerged as important therapies for immuno(onc)ological disorders, but their use is limited by u...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-07-20 | PXD031384 | Pride
Abpp Pbmc Cysteine Allosteric Splenocyte Kinase Jak1 inhibitor 
TranscriptomicsTranscription profiling of human fibrosarcoma cells to study the relative contributions of Jak1 and Jak2 in IFNg signaling
General impact of Jak1 and Jak2 inhibition on IFNg-mediated target gene expression. U4C-Jak1AS and g2A-Jak2AS cells were stimulated with IFNg and treated with either 1NM-PP1 (to inhibit the activity only of the analog-sensitive mutant) or JI1 (to suppress both wild-type and analog-sensitive Jaks) fo...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-MEXP-2621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human JAK1 wild-type and JAK1 mutation-positive T cell acute lymphoblastic leukemia blasts
Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and diff...
ORGANISM(S): Homo sapiens 
2009-10-02 | E-GEOD-18239 | biostudies-arrayexpress
TranscriptomicsGene expression profiling upon knockdown of JAK1 in IM9 cells
Natural Killer (NK) cells are primary effectors of innate immunity directed against transformed cells. In response, tumor cells have developed mechanisms to evade NK cell-mediated lysis but the molecular basis for target cell resistance is not well understood. In the present study, we used a lentivi...
ORGANISM(S): Homo sapiens 
2012-06-27 | E-GEOD-37012 | biostudies-arrayexpress
ModelsSobotta2017 - IL-6-induced JAK1-STAT3-signaling
Here we present a mathematical model of IL-6-induced JAK1-STAT3 signaling that quantitatively links physiological IL-6 concentrations to the dynamics of IL-6-induced signal transduction and expression of target genes in hepatocytes. The mathematical model consists of coupled ordinary differential eq...
2023-07-05 | MODEL2307050001 | BioModels
ProteomicsKupffer cell-derived IL6 promotes hepatocellular carcinoma metastasis via the JAK1-ACAP4 pathway
Tumor-associated macrophages (TAMs), which differentiate from tissue-resident macrophages, are recognized for their ability to influence cancer progression and metastasis. However, the specific role of Kupffer cells, the intrinsic macrophages of the liver, in the progression of hepatocellular carcin...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD057481 | Pride
Mhcc97h，thle-2 
GenomicsCellular spermine targets JAK1 to restrain cytokine-mediated autoimmunity
Cellular spermine targets JAK1 to restrain cytokine-mediated autoimmunity
PRJNA905367 | ENA
GenomicsCellular spermine targets JAK1 to restrain cytokine-mediated autoimmunity (Mouse)
Cellular spermine targets JAK1 to restrain cytokine-mediated autoimmunity (Mouse)
PRJNA923703 | ENA
GenomicsCellular spermine controls autoinflammation by targeting JAK1 to restrain cytokine response
Cellular spermine controls autoinflammation by targeting JAK1 to restrain cytokine response
PRJNA791295 | ENA
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