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MetabolomicsLimited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights
MetabolomicsSystem-level analysis of flux regulation of yeast show that glycolytic flux is controlled by allosteric regulation and enzyme phosphorylation
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST002397 | MetabolomicsWorkbench
GenomicsThe allosteric landscape of the Src kinase
The allosteric landscape of the Src kinase
PRJNA1040239 | ENA
GenomicsAllosteric and Energetic Remodeling by Protein Domain Extensions
Allosteric and Energetic Remodeling by Protein Domain Extensions
PRJEB90076 | ENA
ProteomicsSelective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine
The JAK family of non-receptor tyrosine kinases includes four subtypes (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction downstream of diverse cytokine receptors. JAK inhibitors have emerged as important therapies for immuno(onc)ological disorders, but their use is limited by u...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-07-20 | PXD031384 | Pride
Abpp Pbmc Cysteine Allosteric Splenocyte Kinase Jak1 inhibitor 
GenomicsGlobal mapping of the energetic and allosteric landscapes of protein binding domains
Global mapping of the energetic and allosteric landscapes of protein binding domains
PRJNA762874 | ENA
OtherThe allosteric landscape of the Src kinase
Enzymes catalyze the reactions of life and are the targets of nearly all small molecule drugs. Most drugs inhibit enzymes by binding to conserved active sites, causing problems of specificity and toxicity. Targeting regulatory allosteric sites can increase specificity, overcome drug resistance and t...
ORGANISM(S): Homo sapiens Saccharomyces cerevisiae 
2024-04-27 | GSE247740 | GEO
GenomicsSeven complete comparative maps of allosteric mutations in a protein family
Seven complete comparative maps of allosteric mutations in a protein family
PRJEB90582 | ENA
ProteomicsDistinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
ER aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that excises N-terminal residues off peptides that then bind onto Major Histocompatibility Complex I molecules (MHC-I) and indirectly modulates adaptive immune responses. ERAP1 contains an allosteric regulatory site that accommodates the C...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD039584 | Pride
Hla Mhc class1 Inhibitor Erap1 Aminopetidase Immunopeptidomics Allosteric 
ProteomicsHDX-MS of CHIP wt and K30A mutant
HDX-MS was used to establish that conformational-inhibition-signals extended from the TPR-domain to the U-box of CHIP. This underscores inter-domain allosteric regulation of CHIP by the core molecular chaperones. Defining the chaperone-associated TPR-domain of CHIP as a manager of inter-domain commu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-30 | MSV000079205 | MassIVE
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