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ProteomicsMapping of the local proteome of the Arabidopsis chloroplast intermembrane space by proximity labelling
The chloroplast intermembrane space, located between the outer and inner envelope membranes, plays key roles in protein and lipid trafficking. Currently, the proteome of the intermembrane space is largely uncharacterized, with only a relatively few protein players identified, and thus limiting our u...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-07-08 | PXD072271 | Pride
Ims Lc-msms Chloroplast 
ProteomicsSmall heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
Mitochondria are complex organelles with different compartments, each harboring their own protein quality control factors. While the chaperones of the mitochondrial matrix have been well characterized, it is poorly understood which chaperones protect the mitochondrial intermembrane space. We show th...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD038275 | Pride
Charcot-marie-tooth (cmt) disease Protein quality control Intermembrane space Small heat shock proteins Mitochondria Chaperones 
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 1: proximity labelling
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD057245 | Pride
Mitochondria Yeast 
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 5: MRP17 - AP-MS
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD054381 | Pride
Yeast mitochondrial import 
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 4: AP-MS for Apj1, Pwp2 and Utp18
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD062600 | Pride
Mitochondria Yeast 
UnknownRetro-translocation of mitochondrial intermembrane space proteins.
Not available
S-EPMC4485110 | biostudies-literature
UnknownToc12, a novel subunit of the intermembrane space preprotein translocon of chloroplasts.
Not available
S-EPMC524789 | biostudies-literature
UnknownChloroplast import of an intermembrane space protein is facilitated by translocon components Toc75 and Tic236.
Not available
S-EPMC8573378 | biostudies-literature
UnknownSOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse.
Not available
S-EPMC3009841 | biostudies-literature
UnknownMitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.
Not available
S-EPMC2662054 | biostudies-literature
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