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TranscriptomicsTranscription profiling of bovine nucleus pulposus, carticular cartilage and annulus fibrosus cells to further determine expression in normal and degenerate human intervertebral disc
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
2010-03-05 | E-MEXP-2291 | biostudies-arrayexpress
TranscriptomicsGene expression in embryonic intervertebral disc and vertebrae.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-ß superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue resul...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18647 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of the Developing Axial Skeleton: A role for Tgfbr2 in the Development of the Intervertebral Disc.
This SuperSeries is composed of the following subset Series: GSE18647: Gene expression in embryonic intervertebral disc and vertebrae. GSE18648: TGF-beta and BMP mediated gene expression in cultured sclerotome. Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human intervertebral disc cells treated with varying osmolarity growth medium
Human intervertebral disc tissue was obtained from patients (average age 51 yrs) undergoing surgery for lumbar interbody fusion (n=3) or lumbar disc herniation (n=1). Cells were isolated by sequential pronase-collagenase digestion [3]. Cells were passaged twice in monolayer and suspended at a densit...
ORGANISM(S): Homo sapiens 
2007-08-13 | E-GEOD-1648 | biostudies-arrayexpress
TranscriptomicsLS001A: Aging/Early Degeneration Of The Intervertebral Disc Involves Downregulation Of Canonical Wnt Signaling and Caveolin-1 expression
Objective: Aging and early degeneration of the intervertebral disc (IVD) involves the substition of notochordal cells (NCs) in the nucleus pulposus (NP) by chondrocyte-like cells (CLCs). This study investigated the gene expression profiles involved in this process using NP tissue from both non-chond...
ORGANISM(S): Canis lupus familiaris 
2013-01-31 | E-GEOD-35717 | biostudies-arrayexpress
ProteomicsA proteomic architectural landscape of the healthy and aging human intervertebral disc
The intervertebral disc (IVD) is a joint in the spine that facilitates daily physical activity, comprising of the central nucleus pulposus (NP), surrounded by the annulus fibrosus (AF) and sandwiched between two cartilage endplates that function together as a unit. Changes to the IVD occur with agin...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD017740 | Pride
Proteomics Intervertebral disc Aging 
TranscriptomicsTGF-beta and BMP mediated gene expression in cultured sclerotome.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-beta superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue re...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18648 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of degenerated human intervertebral disc tissues
Mass spectrometry analysis of degenerated human intervertebral disc tissues obtained during elective surgery to treat low back pain
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD056620 | Pride
Human Degeneration Mass spectometry Intervertebral disc Dda 
ProteomicsMatrisome remodelling during Intervertebral Disc development and ageing
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investi...
ORGANISM(S): Bos taurus (Bovine) 
2017-09-25 | PXD005616 | Pride
Foetus Extracellular matrix Development Intervertebral disc Ageing 
ProteomicsActively synthesised proteins in human intervertebral disc
The intervertebral disc (IVD) is a joint in the spine that facilitates daily movement, comprising of the central nucleus pulposus (NP), surrounded by the annulus fibrosus (AF) and sandwiched between two cartilage endplates that function together as a unit. Changes to the IVD occur with aging, most d...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD018193 | Pride
Proteomics Dynamic proteome Intervertebral disc Silac Proteomic architecture Aging 
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