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TranscriptomicsA Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-38782 | biostudies-arrayexpress
UnknownPermanent deconstruction of intracellular primary cilia in differentiating granule cell neurons.
Not available
S-EPMC11320830 | biostudies-literature
UnknownPermanent deconstruction of intracellular primary cilia in differentiating granule cell neurons.
Not available
S-EPMC10723395 | biostudies-literature
ProteomicsMolecular Mechanisms of Stress Granule Disassembly Revealed by Chemogenetic Microenvironment Mapping (MicroMap) in Living Cells
Phase-separated condensates are membrane-less intracellular structures comprised of dynamic protein interactions that organize essential biological processes. Understanding the composition and dynamics of these organelles advances our knowledge of cellular behaviors and disease pathologies related t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-11 | MSV000094520 | MassIVE
UnknownSingle-molecule analysis of intracellular insulin granule behavior and its application to analyzing cytoskeletal dependence and pathophysiological implications.
Not available
S-EPMC10731264 | biostudies-literature
TranscriptomicsMiRNA expression profiling in bone-marrow-derived neutrophils of lcn2 deficient mouse
Lipocalin 24p3 (24p3) is a neutrophil secondary granule protein. 24p3 is also a siderocalin, which binds several bacterial siderophores. It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden sid...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43890 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in bone-marrow-derived neutrophils of lcn2 deficient mouse
Lipocalin 24p3 (24p3) is a neutrophil secondary granule protein. 24p3 is also a siderocalin, which binds several bacterial siderophores. It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden sid...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43889 | biostudies-arrayexpress
ProteomicsIntracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules Implicated in ALS/FTD
Energy metabolism and membraneless organelles have been implicated in human diseases including neurodegeneration. How energy deficiency regulates ribonucleoprotein particles such as stress granules (SGs) is still unclear. Here we identified a unique type of granules formed under energy deficiency an...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD035747 | Pride
Stress granule  energy metabolism  als/ftd  protein homeostasis 
ProteomicsContext-dependent and disease-specific diversity in stress granules formed from preexisting protein interactions
Affinity-capture proteomics studies using endogenously tagged G3BP1 with APEX2 to capture the stress granule proteome at steady state and upon stress induction. This was done in 293T cells as well as induced pluripotent stem cells differentiated into neuronal progenitor cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081554 | MassIVE
ProteomicsProteomic Analysis of Intracellular Biomineralised Granules in the Deep-Sea Hydrothermal Vent Alvinellid Worm Paralvinella herssleri
In this project, we used liquid chromatography coupled with mass spectrometry to sequence the intracellular granules of the deep-sea Alvinellidae worm Paralvinella hessleri. These granules are composed of biomineralized orpiment.
ORGANISM(S): Paralvinella hessleri 
2025-09-08 | PXD051377 | Pride
Paralvinella hessleri Hydrothermal vent Intracellular granule Deep-sea Orpiment biominerlization 
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