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ProteomicsThe catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1
T-Cell Protein Tyrosine Phosphatase (TCPTP, PTPN2) is a non-receptor type protein tyrosine phosphatase that is ubiquitously expressed in human cells. TCPTP is a critical component of a variety of key signaling pathways that are directly associated with the formation of cancer and inflammation. Thus,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD029256 | Pride
Tcptp Ptpn2 Intermolecular cx-ms Intramolecular cx-ms 
ProteomicsCX-MS of Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore
Kinetochores form the link between chromosomes and microtubules of the mitotic spindle. The heterodecameric Dam1 complex (Dam1c) is a major component of the S. cerevisiae outer kinetochore, assembling into 3 MDa-sized microtubule-embracing rings, but how ring assembly is specifically initiated at ki...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-06-28 | PXD026935 | Pride
Mass spectrometry Kinetochore Chemical cross-linking 
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