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MetabolomicsSingle-cell RNA sequencing decipher hepatic injury and APOA4 as a biomarker in males with intrauterine growth restriction

Intrauterine growth restriction (IUGR) is associated with increased relative liver weight at birth, hepatic function decline and a higher risk for chronic liver and cardiovascular diseases in adults. Precise mechanisms of early developmental plasticity to intervene in poor fetal programming and a...

2023-09-25 | MTBLS6881 | MetaboLights
Proteomicsfetal growth restriction_pancreas_differences in nutritional condition
Quantification of proteins in the pancreas of fetal growth restriction.
ORGANISM(S): Rattus Rattus (black Rat) 
2022-06-07 | PXD026502 | JPOST Repository
ProteomicsPROTEOMIC ANALYSIS OF THE UMBILICAL CORD IN FETAL GROWTH RESTRICTION AND PREECLAMPSIA
Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the associated perinatal morbidity and mortality. The structure of the umbilical cord in the setting of FGR and PreE has yet to be determined. This study aimed to examine chan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-15 | MSV000087051 | MassIVE
MetabolomicsSexual dimorphism in the fetal cardiac response to maternal nutrient restriction
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR affects fetal cardiac structure and metabolism. S...
2018-04-30 | MTBLS426 | MetaboLights
TranscriptomicsIntrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model
Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in th...
ORGANISM(S): Oryctolagus cuniculus 
2013-10-30 | E-GEOD-37860 | biostudies-arrayexpress
TranscriptomicsGene expression profiling indicates inflammatory pathways involved in IUGR due to placental insufficiency
Intrauterine growth restriction (IUGR) represents a major obstetric challenge with perinatal complications and a risk factor of developing disease in adult life. Placental insufficiency is one of the common features accompanying IUGR. The aim of this study was to evaluate global placental gene ...
ORGANISM(S): Homo sapiens 
2008-08-01 | E-GEOD-12216 | biostudies-arrayexpress
ProteomicsProteomic analysis of liver proteome affected by intrauterine growth restriction in newborn piglets.
Intrauterine growth restriction (IUGR) impairs fetal growth and development, perturbs nutrient metabolism, and increases the risk of developing diseases in the postnatal life. However, the underlying mechanisms by which IUGR affects fetuses remain incompletely understood. Here, we applied high-throu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2016-03-15 | PXD003524 | Pride
Newborn piglets Liver Intrauterine growth restriction Proteome 
TranscriptomicsExpression analysis of genes in Rattus norvegicus lungs at postnatal day 4, 10 and 21 after intrauterine growth restriction induced by low protein diet
We performed RNA microarray in a low protein diet (LPD) model of IUGR at three key time points of alveolarization process. IUGR and control rat pups had been studied for each time point considered: on postnatal day 4 (P4) before beginning of the alveolarization process, on P10, peak of alveolarizat...
ORGANISM(S): Rattus norvegicus 
2014-10-29 | E-GEOD-56956 | biostudies-arrayexpress
ProteomicsThe proteome landscape of human placentas for monochorionic twins with selective intrauterine growth restriction
In this study, we profiled the placental proteome of IUGR twins and normal cotwins from 6 monochorionic twin pairs with selective intrauterine growth restriction (sIUGR).
ORGANISM(S): Homo Sapiens 
PXD035369 |
TranscriptomicsGenome-wide DNA methylation in normal and IUGR pancreatic islets
Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-16839 | biostudies-arrayexpress
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