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ProteomicsRegulation of Src tumor activity by its N-terminal intrinsically disordered region
The membrane anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conformations. However, Src contains a N-terminal i...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD030006 | Pride
Cell transformation Cell signaling Protein kinase Intrinsically disordered region 
ProteomicsDNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1
Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, PRC1, has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting/nucleosome bridging activity that can inhibit transcription and chromatin remodeling. In Drosophila, the...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-05-15 | MSV000085418 | MassIVE
ProteomicsProtection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-14 | PXD031972 | Pride
Sq motifs Rif1 Dsb resection inhibition Dna replication fork protection Intrinsically disordered region 
UnknownInfluence of sequence changes and environment on intrinsically disordered proteins.
Not available
S-EPMC2727479 | biostudies-literature
UnknownArchaic chaos: intrinsically disordered proteins in Archaea.
Not available
S-EPMC2880407 | biostudies-literature
UnknownAnalysis of structured and intrinsically disordered regions of transmembrane proteins.
Not available
S-EPMC2887740 | biostudies-literature
ProteomicsMultiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
Transcription factors harbour defined intrinsically disordered regulatory regions, which raises the question of how they mediate binding to structured co-regulators and how this regulates activity. Here, we present a detailed molecular regulatory mechanism of Forkhead box O4 (FOXO4) by the structure...
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD026263 | Pride
Foxo signalling Post-translational modification Icat Structural biology Intrinsically disordered proteins Nmr spectroscopy Transcription factors Wnt signalling -catenin Phosphorylation 
GenomicsReplication licensing regulated by an intrinsically disordered region of origin recognition complex
Replication licensing regulated by an intrinsically disordered region of origin recognition complex
PRJNA1093011 | ENA
ProteomicsMultisite phosphorylation of intrinsically disordered region of Dishevelled
When WNT binds to its receptor Frizzled (FZD) to activate the signaling, Dishevelled (DVL), the central component of Wnt signaling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are k...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2026-04-07 | PXD063470 | Pride
Dishevelled Phosphorylation Hdx-ms 
ProteomicsTMT isobaric profiling of PPIA heterozygous versus knockout haematopoietic stem cells
Mass spectrometry was performed with an Orbitrap Fusion Tribrid mass spectrometer (Thermo Scientific) interfaced with an UltiMate 3000 Binary RSLCnano System (Dionex). Proteome Discoverer v.1.4 (Thermo Scientific) with SEQUEST HT search engines was used for the spectra-preprocessing and HCD MS2 spec...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-10-16 | MSV000093127 | MassIVE
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