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ProteomicsNeuronal aging leads to disrupted RNA metabolism
Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged (i.e. >50 yea...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD055826 | Pride
Human Neuron Transdifferentiation 
TranscriptomicsOccupancy and transcriptional profile of Prdm12 in posteriorized neural tissue
V1 interneurons are a class of inhibitory neurons that play an essential role in vertebrate locomotion; however, the factors contributing to their specification are poorly understood. Morphological and molecular evidence suggest that the zinc finger transcription factor Prdm12 may play a role in pro...
ORGANISM(S): Xenopus laevis 
2015-11-04 | E-GEOD-64551 | biostudies-arrayexpress
TranscriptomicsHaemophilus ducreyi 35000HPfis relative to 35000HP
The goal of this study was to compare the global trascription profile of a Haemophilus ducreyi fis deletion mutant to that of the wild type parental strain. This study includes three biological replicates (paired samples of mutant and wild type strains), and all three were subjected to dye swap.
ORGANISM(S): Haemophilus ducreyi 
2013-11-04 | E-GEOD-44413 | biostudies-arrayexpress
GenomicsEssential role of poly(ADP-ribosyl)ation in cocaine action
Many of the long-term effects of cocaine on the brain's reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin modifications, including histone acetylation and methylation, have been implicated in this regulation, but the effect of other histone modifica...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-55136 | biostudies-arrayexpress
TranscriptomicsCFIm25 links alternative polyadenylation to glioblastoma tumour suppression
Purpose: To identify all of the APA targets of CFIm25 on a global scale and develop an algorithm that can idenitify APA events from standard RNA-seq data Methods: RNA from HeLa cells treated with control siRNA and CFIm25 siRNA were subject to RNA-Seq. Using a custom-designed algorithm to mine RNA-s...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-42420 | biostudies-arrayexpress
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