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TranscriptomicsiPSC derived motor neuron cultures from C9ORF72 carriers
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative condition characterized by loss of motor neurons in the brain and spinal cord. Expansions of a hexanucleotide repeat (GGGGCC) in the noncoding region of the C9ORF72 gene are the most common cause of the familial form of ALS (C9-ALS), ...
ORGANISM(S): Homo sapiens 
2013-11-07 | E-GEOD-52202 | biostudies-arrayexpress
ProteomicsAnalyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets
Supporting MS data files for paper (doi:10.3389/fncel.2023.1327361) by Watts M.E. et al., titled "Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets". See attached pdf for index of MS files uploaded.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-25 | MSV000093190 | MassIVE
GenomicsGene expression from human iPSC derived motor neurons.
Gene expression from human iPSC derived motor neurons.
EGAS00001003785 | EGA
TranscriptomicsTranscriptional profiling of iPSC derived motor neurons from spinal and bulbar muscular atrophy patients at key stages motor neurogenesis
Characterise the molecular pathogenesis of androgen receptor spinal and bulbar muscular atrop (SBMA) causing repeat expansion mutations in human motor neurons generated from patient-specific spinal cord motor neurons from induced pluripotent stem cells and performed time-resolved analysis of transcr...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-15765 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profile and splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPSC) obtained by reprogramming SMA patient and his healthy father fibroblasts, and gene...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27205 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of native and disease-corrected motor neurons from human spinal muscular atrophy induced pluripotent stem cells free of vector and transgenic sequences
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27207 | biostudies-arrayexpress
TranscriptomicsGene expresssion in human iPSC-derived neurons from normal and SPG3A donors
We performed RNA-seq experiments on two samples (cortical neurons and spinal motor neurons) from normal induced pluripotent stem cells (iPSCs), and another two samples (cortical neurons and spinal motor neurons) derived from SPG3A (an early onset form of hereditary spastic paraplegia) iPSCs. This in...
ORGANISM(S): Homo sapiens 
2019-03-25 | E-MTAB-7770 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of polyA tailed RNA from mutant SOD1 and isogenic control human motor neurons
Amyotrophic Lateral Sclerosis is a fatal neurodegenerative disorder that affects motor neurons (MN). We used single cell RNA-seq of degenerating human MN derived from ALS patients to understand molecular drivers of MN degeneration. Patient-derived iPSC bearing a point mutation in the SOD1 gene (SOD1...
ORGANISM(S): Homo sapiens 
2019-11-01 | E-MTAB-7353 | biostudies-arrayexpress
ProteomicsLiver Steatosis and Mitochondrial Dysfunction in Spinal Muscular Atrophy is Survival Motor Neuron-Dependent and Hepatocyte-Intrinsic
Spinal Muscular Atrophy (SMA) is typically characterized as a motor neuron disease, but extra-neuronal phenotypes are present in almost every organ in severely affected patients and animal models. Extra-neuronal phenotypes were previously underappreciated as patients with severe SMA phenotypes usual...
ORGANISM(S): Homo Sapiens (human) 
2024-05-09 | PXD045401 | JPOST Repository
ProteomicsALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons
Mutations in the AAA+ ATPase p97 cause multisystem proteinopathy 1 which includes amyotrophic-lateral sclerosis; however, the pathogenic mechanisms that contribute to motor neuron loss remain obscure. Here, we use two induced pluripotent stem cell models differentiated into spinal motor neurons to i...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-08 | PXD048185 | Pride
Ubxd1 Lysosome Human motor neurons Cb-5083 P97 
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