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ProteomicsIRF2BP2 counteracts the ATF7/JDP2 heterodimer to prevent inflammatory overactivation in AML cells
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the abnormal proliferation and accumulation of immature myeloid cells in the bone marrow. Inflammation plays a crucial role in AML progression, but excessive activation of inflammatory pathways can also trigger cell death. I...
ORGANISM(S): Homo sapiens (Human) 
2024-05-16 | PXD041817 | Pride
Interferon Atf7 Transcriptional regulation Irf2bp2 Jdp2 Inflammation Aml 
GenomicsIRF2BP2 promotes neuroblastoma progression
IRF2BP2 promotes neuroblastoma progression
PRJNA990742 | ENA
TranscriptomicsMicroarray expression profiling of male and female bone marrow derived macrophages from wild type and lysMCre/Irf2bp2flox mice
Interferon regulatory factor 2 binding protein 2 (Irf2bp2) is a corepressor of Irf2 that suppresses inflammatory gene expression and promotes the M2 macrophage phenotype in bone marrow derived macrophages (BMDM). Loss of Irf2bp2 in male macrophages promotes an inflammatory phenotype. Here, we compar...
ORGANISM(S): Mus musculus domesticus 
2024-09-01 | E-MTAB-14166 | biostudies-arrayexpress
TranscriptomicscDNA microarray expression data of heart, skeletal muscle and liver comparing Irf2bp2-null mice to wild type controls
Interferon regulatory factor 2 binding protein 2 (Irf2bp2), a co-repressor of Irf2, is required for fetal hepatic erythropoiesis through the expansion of erythromyeloid progenitors. Mice with germline ablation of the entire Irf2bp2 transcript produced no viable Irf2bp2-null (knockout, KO) pups in fi...
ORGANISM(S): Mus musculus 
2023-02-02 | E-MTAB-11558 | biostudies-arrayexpress
GenomicsIRF2BP2 Modulates Chromatin Accessibility in Neuroblastoma
IRF2BP2 Modulates Chromatin Accessibility in Neuroblastoma
PRJNA1031214 | ENA
GenomicsTranscriptional regulation of adipocyte lipolysis by IRF2BP2 [ChIP-seq]
Transcriptional regulation of adipocyte lipolysis by IRF2BP2 [ChIP-seq]
PRJNA1184140 | ENA
GenomicsTranscriptional regulation of adipocyte lipolysis by IRF2BP2 [RNA-seq]
Transcriptional regulation of adipocyte lipolysis by IRF2BP2 [RNA-seq]
PRJNA1184141 | ENA
GenomicsTranscriptional regulation of adipocyte lipolysis by IRF2BP2 [CUT&RUN]
Transcriptional regulation of adipocyte lipolysis by IRF2BP2 [CUT&RUN]
PRJNA1184145 | ENA
TranscriptomicsIRF2BP2 promotes neuroblastoma progression
We report a previously unrecognized role of IRF2BP2 in neuroblastoma. To explore IRF2BP2-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the IRF2BP2-knockdown SK-N-BE(2) cells in comparison to control group. We find that IRF2BP2 contribu...
ORGANISM(S): Homo sapiens 
2024-06-24 | GSE236390 | GEO
UnknownTranscriptional regulation of adipocyte lipolysis by IRF2BP2.
Not available
S-EPMC11698119 | biostudies-literature
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