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MetabolomicsAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation

Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical m...

2026-05-07 | MTBLS14445 | MetaboLights
GenomicsIRF4 ChIP-on-chip for Myeloma Cell Lines
To identify IRF4 transcription factor binding on chromatin at 5' regulatory regions of genes in myeloma cell line models. Keywords: binding site identification design Formaldehyde cross-linked, sonicated chromatin is prepared from cell lines Kms12 (test) and Ly19 (control). Chromatin immunoprecipate...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-9367 | biostudies-arrayexpress
TranscriptomicsEssential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma survival
Three ALCL cell lines DEL, FEPD and K299 were induced with an IRF4-specific shRNA for up to 96 hours. The three ALCL cell lines DEL, FEPD and K299 were induced with an IRF4-specific shRNA for four durations and compared with the corresponding not-induced control.
ORGANISM(S): Homo sapiens 
2015-01-03 | E-GEOD-59747 | biostudies-arrayexpress
TranscriptomicsMyeloma IRF4 target genes - Agilent
The goal of this gene expression study was to identify genes whose expression depends on the transription factor IRF4 by knocking down it's expression using shRNA in two IRF4+ myeloma cell lines. Keywords: time series design Two myeloma lines were analyzed over a time course of IRF4-targeted shRNA i...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9067 | biostudies-arrayexpress
GenomicsSPIB and BATF provide alternate determinants of IRF4 occupancy in Diffuse Large B-cell Lymphoma linked to disease heterogeneity
ChIP-seq data for the transcription factors (TFs) IRF4, PU.1 and SPIB from the cell lines OCI-LY3, OCI-LY10 and H929, and BATF from the cell lines OCI-Ly3 and OCI-Ly10. In addition ChIP-seq for the TFs IRF4, PU.1 and SPIB from the cell line OCI-LY3 following transfections of scramble/SPIB-siRNA. ChI...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-56857 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of IRF4 -/- vs IRF4 +/- T-cells under Th17 polarizing conditions
Transcriptional profiling of T-cells isolated from spleen of IRF4 -/- mice and cultured under Th17 polarizing conditions for 42 hrs compared to cells similarly isolated and cultured from spleen of IRF4 +/- mice. The aim of the study was to identify global misexpression of genes in IRF4 -/- cells and...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-40726 | biostudies-arrayexpress
TranscriptomicsIRF4 and Myeloma
Using RNA interference to identify IRF4 target genes. Keywords: time series design Gene expression was analyzed using Lymphochip cDNA spotted arrays. Myeloma cell lines were infected with control (shluc, Cy3) or shIRF4 (Cy5) constructs, and changes in gene expression were monitored over time after i...
ORGANISM(S): Homo sapiens 
2008-07-07 | E-GEOD-8958 | biostudies-arrayexpress
GenomicsThe transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells [ChIP-seq]
We demonstrate that transcription factor IRF4 is induced in a T cell receptor (TCR) affinity-dependent manner and functions as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulates the expression of key molecules required for aerobic glycolysis of effector T cells...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-49930 | biostudies-arrayexpress
GenomicsBATF-JUN is critical for IRF4-mediated transcription in T cells
Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cell...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-39756 | biostudies-arrayexpress
ProteomicsAdipocyte-Derived β-Hydroxybutyrate Confers Metabolic Stress Resistance in Multiple Myeloma-2
Despite being recognized as a major mesenchymal cell type and a key accomplice in myeloma progression, the precise roles of adipocytes in distinct stages of myeloma pathogenesis remain elusive. Here, we elucidate a critical role of adipocyte-derived β-hydroxybutyrate (β-OHB) in enabling myeloma cel...
ORGANISM(S): Homo sapiens (Human) 
2026-05-07 | PXD065472 | Pride
Irf4 Acetylation Multiple myeloma Adipocytes Β-hydroxybutyrate 
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