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TranscriptomicsMicroarray of murine C2C12 myoblast treated with irisin against untreated control
Irisin is a recently identified myokine that is induced by exercise and stimulates brown-fat-like development of white fat and energy expenditure in humans and mice. In this study, we aimed to evaluate the pro-proliferative effect of irisin on C2C12 myoblasts and its mechanisms of action.
ORGANISM(S): Mus musculus 
2019-08-13 | E-MTAB-8180 | biostudies-arrayexpress
ProteomicsIrisin acts through its integrin receptor in a novel two-step process
Exercise benefits the human body in many ways. Irisin is secreted by muscle, increased with exercise, and conveys many physiological benefits, including improved cognition and resistance to neurodegeneration. Irisin acts via αV integrins; however, a mechanistic understanding of how small polypeptide...
ORGANISM(S): Homo sapiens (Human) 
2023-06-04 | PXD035397 | Pride
Irisin  integrin  hdx-ms  hydrogen/deuterium exchange mass spectrometry  polypeptide hormone  αvβ5 
ProteomicsAmelioration of Pathologic -Synuclein-Induced Parkinson’s Disease by Irisin
Physical activity is thought to provide clinical benefit in Parkinson’s diseas (PD). Irisin is a blood-brain barrier permeable exercise-induced polypeptide secreted by muscle that mediates, in part, the beneficial effects of exercise. Here we show that irisin prevents pathologic -synuclein (-syn) in...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD032670 | Pride
Irisin Alpha-synuclein Neurodegeneration Parkinson’s disease 
TranscriptomicsIrisin is a Pro-Myogenic Factor that Induces Skeletal Muscle Hypertrophy and Rescues Denervation-Induced Atrophy
C2C12 myoblasts were seeded at a density of 25,000 cells/cm2 in a 10cm cell culture dish and differentiated with low serum differentiation medium at 37 °C, 5% CO2 for 72h and further treated with either DB or recombinant Irisin protein (1000ng/ml) for 6h, 12h, 24h and 48h. Myotubes were resuspended ...
ORGANISM(S): Mus musculus 
2017-09-11 | E-MTAB-6024 | biostudies-arrayexpress
GenomicsIrisin regulated genes in mouse liver derived AML12 cells
Irisin regulated genes in mouse liver derived AML12 cells
PRJNA971191 | ENA
GenomicsMyokine irisin is a critical regulator of cognitive function I
Myokine irisin is a critical regulator of cognitive function I
PRJNA728741 | ENA
GenomicsMyokine irisin is a critical regulator of cognitive function III
Myokine irisin is a critical regulator of cognitive function III
PRJNA742071 | ENA
GenomicsIrisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
Irisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
PRJNA1191051 | ENA
GenomicsMyokine irisin is a critical regulator of cognitive function II
Myokine irisin is a critical regulator of cognitive function II
PRJNA728744 | ENA
GenomicsIrisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
Irisin improves obesity and glucose intolerance through an IL-33-ST2 pathway
PRJNA1192701 | ENA
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