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The project was aimed at identifying deubiquitinases (DUBs) involved in cancer cell mechanosignaling. Lysates from cancer cells grown on collagen matrices with varying stiffnesses were incubated with an activity-based HA-tagged ubiquitin probe that covalently binds DUB active site. To identify DUBs ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-22 | PXD054010 | Pride
Protein synthesis plays a central role in cancer development and progression. eIF5A (eukaryotic initiation factor 5A), a translation factor activated by hypusination, is implicated in tumorigenesis, however, its mode of action is still unclear. Hypusinated eIF5A (eIF5Ahyp) promotes metastasis and tu...
ORGANISM(S): Homo sapiens (Human) 
2026-01-30 | PXD058627 | Pride
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