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Transcriptomicssmall RNA-Seq of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury
Ischemic preconditioning is effective in limiting subsequent ischemic acute kidney injury in experimental models. microRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. An evaluation was performed of the time- and dose-dependent effects o...
ORGANISM(S): Rattus norvegicus 
2021-12-31 | E-MTAB-9896 | biostudies-arrayexpress
TranscriptomicsExiqon miRCURY microRNA array of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury
Ischemic preconditioning is effective in limiting subsequent ischemic acute kidney injury in experimental models. microRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. An evaluation was performed of the time- and dose-dependent effects o...
ORGANISM(S): Rattus norvegicus 
2021-12-31 | E-MTAB-9900 | biostudies-arrayexpress
TranscriptomicsRemote ischemic preconditioning in on-pump coronary artery bypass graft surgery
In this placebo-controlled randomized controlled trial, we tested whether remote ischemic preconditioning (RIPC) elicited by four 5-minute cycles of 300 mmHg of cuff inflation/deflation of the lower limb would reduce myocardial necrosis in isoflurane-anesthetized patients undergoing on-pump coronary...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-29396 | biostudies-arrayexpress
MetabolomicsUntargeted Metabolomics Reveals a Mild Impact of Remote Ischemic Conditioning on the Plasma Metabolome and α-Hydroxybutyrate as a Possible Cardioprotective Factor and Biomarker of Tissue Ischemia
Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. heart attacks. As RIC can be induced using a simple blood pressure cuff e.g. prior to revascularization, it con...
2016-12-20 | MTBLS414 | MetaboLights
TranscriptomicsTranscription profiling of Wistar rat preconditioned hearts either perfused alone or subjected to ischemia and then reperfused
Isolated perfused rat hearts exposed to isoflurane or ischemic preconditioning, a subgroup followed by 40 minutes of ischemia and 3 hours of reperfusion. Exact protocol available from the authors.
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1616 | biostudies-arrayexpress
TranscriptomicsMicroglia in ischemic brain injury
Microglia are resident CNS immune cells that are active sensors in healthy brain and versatile effectors under pathological conditions. Cerebral ischemia induces a robust neuroinflammatory response that includes marked changes in the gene expression and phenotypic profile of a variety of endogenous ...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-18602 | biostudies-arrayexpress
ProteomicsAttenuated inflammatory profile following single and repeated handgrip exercise and remote ischemic preconditioning in patients with cerebral small vessel disease
Similar to remote ischemic preconditioning bouts of exercise may possess immediate protective effects against ischemia-reperfusion injury. However, underlying mechanisms are largely unknown. This study compared the impact of single and repeated handgrip exercise versus remote ischemic preconditionin...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037267 | Pride
Exercise Inflammation Remote ischemic preconditioning Cerebral small vessel disease Proteomics. 
TranscriptomicsProfiling Period 2 (PER2) mediated pathways following ischemic preconditioning (IPC) of the mouse heart using a genome array with 352 abundantly expressed and well-characterized micro RNAs
Ischemic preconditioning (4 cycles of 5 min ischemia and 5 min reperfusion) with a final reperfusion time of 120 minutes was performed in C57BL/6N (The Jackson Laboratory) or Per2-/- mice. Heart tissue was snap-frozen with clamps pre-cooled to the temperature of liquid nitrogen. Micro RNA was isolat...
ORGANISM(S): Mus musculus 
2017-04-12 | E-MTAB-5401 | biostudies-arrayexpress
TranscriptomicsGlobal Gene Expression in Deceased Donor Liver Transplantation with Ischemic Preconditioning
The clear benefits of ischemic preconditioning (IPC) in reducing ischemia reperfusion injury (IRI) remain indistinct in human liver transplantation. To further understand the mechanistic aspects of IPC in human deceased donor liver transplantation (DDLT), we performed microarray analyses to determin...
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15480 | biostudies-arrayexpress
TranscriptomicsMouse ischemic tolerance genomic analysis of the brain and blood.
Ischemic tolerance can be induced by numerous preconditioning stimuli, including various Toll-like receptor (TLR) ligands. We have shown previously that systemic administration of the TLR4 ligand, lipopolysaccharide (LPS) or the TLR9 ligand, unmethylated CpG ODNs prior to transient brain ischemia in...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-32529 | biostudies-arrayexpress
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