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TranscriptomicsClinical Significance of Osteoprotegerin Expression in Human Colorectal Cancer
Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. Overexpression in CRC...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-21510 | biostudies-arrayexpress
TranscriptomicsOverexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery (copy number analysis)
Purpose: The purpose of this study is to identify a novel biomarker related with distant metastases of colorectal cancer (CRC). Experimental Design: We investigated mRNA expression profiles in 115 patients with CRC using an Affymetrix Gene Chip, and copy number profiles in 122 patients with CRC usin...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-27910 | biostudies-arrayexpress
TranscriptomicsOverexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery (gene expression analysis)
Purpose: The purpose of this study is to identify a novel biomarker related with distant metastases of colorectal cancer (CRC). Experimental Design: We investigated mRNA expression profiles in 115 patients with CRC using an Affymetrix Gene Chip, and copy number profiles in 122 patients with CRC usin...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-27854 | biostudies-arrayexpress
TranscriptomicsStage II and stage III colorectal cancer
Distant metastasis is the major causes of death in colorectal cancer (CRC) patients. In order to identify genes influencing the prognosis of patients with CRC, we compared gene expression in primary tumors with and without distant metastasis using an oligonucleotide microarray. We also examined the ...
ORGANISM(S): Homo sapiens 
2010-03-05 | E-GEOD-18105 | biostudies-arrayexpress
TranscriptomicsJuvenile idiopathic arthritis: peripheral blood cells
Systemic-onset juvenile idiopathic arthritis (soJIA) is a rheumatic disease in childhood characterized by systemic symptoms and a relatively poor prognosis. The peripheral leukocytes are thought to play the pathological role of soJIA although the exact cause is still obscure. In this study, we aimed...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8361 | biostudies-arrayexpress
TranscriptomicsPrognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [gene expression]
Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells ...
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-64256 | biostudies-arrayexpress
TranscriptomicsPrognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [copy number analysis]
Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells ...
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-64257 | biostudies-arrayexpress
TranscriptomicsHuman peripheral blood cells (PB): Effect of Tocilizumab/MRA compared to methotrexate(MTX) treatments on rheumatoid arthritis(RA) patients.
This microarray study was conducted along with SATORI study, the clinical trial evaluated 125 patients with active RA with an inadequate response to low dose of MTX. Patients were allocated to receive either Tocilizumab(TCZ) 8 mg/kg every 4 weeks (TCZ group) or MTX 8 mg/week (MTX/control group) for ...
ORGANISM(S): Homo sapiens 
2014-01-29 | E-GEOD-35455 | biostudies-arrayexpress
TranscriptomicsHuman peripheral blood cells: systemic lupus erythematosus vs healthy individual.
Gene expression profiling of peripheral blood cells from patients with systemic lupus erythematosus (SLE) vs healthy individual (HI). Peripheral blood was obtained from patients with SLE (n=21) and HI (n=45). Blood samples from 45 HI are used as control.
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-20864 | biostudies-arrayexpress
TranscriptomicsEnhanced Phospholipase A2 group 3 expression by oxidative stress decreases the insulin-degrading enzyme
Oxidative stress has a ubiquitous role in neurodegenerative diseases and oxidative damage in specific regions of the brain is associated with selective neurodegeneration. We previously reported that Alzheimer disease (AD) model mice showed decreased insulin-degrading enzyme (IDE) levels in the cere...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75047 | biostudies-arrayexpress
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