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ProteomicsIsobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes
Dynamic conformational and structural changes in proteins and protein complexes play a central and ubiquitous role in the regulation of protein function, yet it is very challenging to study these changes, especially for large protein complexes, under physiological conditions. Here we introduce a nov...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-11-13 | PXD056825 | Pride
Isobaric crosslinkers Qclms Conformational changes Quantitative crosslinking mass spectrometry 
ProteomicsAn isobaric quantitative crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and protein complexes
Experimental determination of protein conformational states is crucial to understand the mechanism of protein function and how function is altered in disease. We introduce a novel, simple and compact, isobaric crosslinker design for studying conformational and structural changes using quantitative m...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-11-13 | PXD035939 | Pride
Conformational change. Qclms Q2linkers Qlinker Isobaric 
ProteomicsQuantitative Analysis of Samples Labeled with Multiplex iqPIR Cross-Linkers
The isobaric quantitative protein interaction reporter (iqPIR) has now been extended to six channels, enabling quantitation of cross-links from six different samples simultaneously. To analyze data for such cross-linkers, the two-channel mode of quantitative analysis was extended to accommodate any...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025796 | Pride
Quantitative analysis Mass spectrometry Crosslinking Multiplex iqpir 
ProteomicsPhoXplex: Combining phospho-enrichable crosslinking with isobaric labelling for quantitative proteome-wide mapping of protein interfaces
Integrating crosslinking mass spectrometry (XL-MS) into structural biology workflows provides valuable information about the spatial arrangement of amino acid stretches, which can guide elucidation of protein assembly architecture. Additionally, combination of XL-MS with peptide quantitation techniq...
ORGANISM(S): Homo sapiens (Human) 
2024-10-21 | PXD052480 | Pride
Isobaric labelling Phospho-enrichable crosslinking 
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