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TranscriptomicsLiver expression data from 31 mouse strains treated with vehicle or isoniazid for 3 days
Isoniazid induced varying degrees of hepatic steatosis in an inbred strain Mouse Diversity Panel (MDP) study. RNA was isolated from all animals for analysis of gene expression changes in the liver. The objective of this study was to identify gene expression changes that drive isoniazid-induced steat...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-55489 | biostudies-arrayexpress
GenomicsIsoniazid resistant TB in South Africa
Isoniazid resistant TB in South Africa
PRJEB67660 | ENA
ProteomicsProteomics of Mycobacterium tuberculosis Beijing genotype after acquisition of Isoniazid resistance
This project provides the first characterization of protein differences in clinical isolates of Mtb after acquisition of resistance to isoniazid (INH), one of the most important drug treatment options against TB. This study determines the global protein differences in a clinical isogenic pair of Mtb...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2016-03-14 | PXD002986 | Pride
Isoniazid Tuberculosis Resistance Ltq Proteomics Mycobacterium Beijing Lc-ms/ms 
ProteomicsProtein profile at different cellular fractions of Mycobacterium tuberculosis strains after exposure to Isoniazid
Out of the 10 million of tuberculosis (TB) cases estimated in the world, around 14% are isoniazid (INH) resistant among new cases and 29% among previously treated cases in the last decade. INH is one of the oldest but also one of the more potent drugs to eliminate Mycobacterium tuberculosis (Mtb), t...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2019-06-17 | PXD007588 | Pride
Cellular fractions Tuberculosis Isoniazid Shotgun proteomics Lc-ms/ms 
ProteomicsComprehensive biochemical characterization of Mycobacterium tuberculosis clonal strains after isoniazid resistance
This project describes the isoniazid (INH) resistance acquisition event in Mycobacterium tuberculosis (Mtb) from the proteomics perspective. In this way, an exploration of the protein differences, comparing clonal INH susceptible (INHs) and INHr pairs of Mtb were evaluated. One clonal clinical and o...
ORGANISM(S): Mycobacterium tuberculosis 
2018-06-25 | PXD009549 | Pride
Mycobacterium tuberculosis Isoniazid resistance 
GenomicsMycobacterium tuberculosis transcriptional response to Isoniazid
Mycobacterium tuberculosis transcriptional response to Isoniazid
PRJNA694989 | ENA
ProteomicsToxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid
Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of hPXR-mediated hepatotoxicity and systemic toxicity of antitubercular drugs. The antit...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-19 | PXD019505 | Pride
Anemia  antitubercular therapy  cytochrome p450  drug-induced liver injury  heme biosynthesis  hypercoagulability  iron–sulfur cluster  pellagra  vitamin b3  vitamin b6 
TranscriptomicsEffect of addition of cysteine to isoniazid treatment of Mycobacterium tuberculosis
Transcriptional profiling of Mycobacterium tuberculosis H37Rv after 4 hours of combination isoniazid and cysteine treatment relative to treatment with isoniazid alone.
ORGANISM(S): Mycobacterium tuberculosis 
2017-03-27 | GSE86184 | GEO
GenomicsEffects of manganese and its concomitant administration with isoniazid on macrophages infected with Mycobacterium tuberculosis
Effects of manganese and its concomitant administration with isoniazid on macrophages infected with Mycobacterium tuberculosis
PRJNA871274 | ENA
TranscriptomicsLiver expression data from 31 mouse strains treated with vehicle or isoniazid for 3 days
Isoniazid induced varying degrees of hepatic steatosis in an inbred strain Mouse Diversity Panel (MDP) study. RNA was isolated from all animals for analysis of gene expression changes in the liver. The objective of this study was to identify gene expression changes that drive isoniazid-induced steat...
ORGANISM(S): Mus musculus 
2014-06-03 | GSE55489 | GEO
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