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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
TranscriptomicsTranscription profile of adipose derived mesenchymal stem cells separated by cell surface protein N-cadherin.
Mesenchymal stem cells (MSCs) are one of most promising stem cell sources for regenerative medicine. MSCs have a differention ability into several tissues. However, their differentiation efficiency is considered quite limited. Especially, the differentiation efficiency into cardiomyocytes is very lo...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-35232 | biostudies-arrayexpress
MetabolomicsFruit setting rewires central metabolism via gibberellin cascades
Fruit set is the process whereby ovaries develop into fruits after pollination and fertilization. The process is induced by the phytohormone gibberellin (GA) in tomatoes, as determined by the constitutive GA response mutant procera However, the role of GA on the metabolic behavior in fruit-setting o...
2020-09-11 | MTBLS1892 | MetaboLights
TranscriptomicsGene expression signatures for human iPS cell lines
The reprogramming of human fibroblasts to generate induced pluripotent stem cells (hiPSCs) has been achieved through the expression of only a few exotic factors1-8, which is morphologically and molecularly verified in outer cellular states by characteristic markers, due to the remodeling of the soma...
ORGANISM(S): Homo sapiens 
2011-03-07 | E-GEOD-20750 | biostudies-arrayexpress
TranscriptomicsDownregulation of the Wnt antagonist Dkk2 links loss of Sept4 and myofibroblastic transformation of hepatic stellate cells
Background/Aims: Sept4, a subunit of the septin cytoskeleton specifically expressed in quiescent hepatic stellate cells (HSCs), is downregulated through transdifferentiation to fibrogenic and contractile myofibroblastic cells. Since Sept4?/? mice are prone to liver fibrosis, we examined the unknown ...
ORGANISM(S): Mus musculus 
2012-06-02 | E-GEOD-24588 | biostudies-arrayexpress
UnknownGWAS with principal component analysis identifies a gene comprehensively controlling rice architecture.
Not available
S-EPMC6800328 | biostudies-literature
Transcriptomicscomparison of mRNA expression among rat hepatoma cell lines with different metastatic ability
To reduce cancer mortality, understanding of mechanisms of cancer metastasis is crucial. We have established 6 rat hepatocellular carcinoma (HCC) cell lines, which exhibit differing metastatic potential to the lung after inoculation into the tail veins of nude mice. Micorarray analysis of 4 kinds of...
ORGANISM(S): Rattus norvegicus 
2012-06-20 | E-GEOD-30469 | biostudies-arrayexpress
TranscriptomicsInsulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb
In this study, we demonstrate that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from hippocampus and olfactory bulb. Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampus and olfactory bulb-derived ...
ORGANISM(S): Rattus norvegicus 
2012-03-14 | E-GEOD-27956 | biostudies-arrayexpress
TranscriptomicsThe induced APL cells generated by the transplantation of PML-RARA-transduced human CD34+ hematopoietic cells into immunodeficient mice
A humanized in vivo APL model has been established utilizing the retroviral transduction of PML-RARA into human CD34+ hematopoietic cells and the transplantation of these cells into immunodeficient mice. The resultant leukemia recapitulated human APL phenotypically, and was clustered in the same cat...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-49344 | biostudies-arrayexpress
TranscriptomicsPseudomonas-derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate
A Pseudomonas aeruginosa-derived neutral ceramidase (PaCDase) isolated from a patient with atopic dermatitis was shown to effectively degrade ceramide in the presence of Staphylococcus aureus-derived lipids or neutral detergents. To understand the effect of ceramide metabolites on the functions of d...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-53670 | biostudies-arrayexpress
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