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ProteomicsThe Combination of Remdesivir and Ivermectin Exerts Highly Potent and Synergistic Antiviral Activity Against Murine Coronavirus and SARS-CoV-2 Infections
The COVID-19 pandemic highlighted the urgent need to develop effective and broad-spectrum antiviral therapies against coronaviruses. One strategy to address this concern is combination therapy using repurposed drugs against zoonotic viruses with pandemic potential. We previously demonstrated that th...
ORGANISM(S): Mus musculus (Mouse) Betacoronavirus 
2026-09-07 | PXD073706 | Pride
Remdesivir  ivermectin  combination therapy  repurposed drugs  murine hepatitis virus  proteomics  transcriptomics 
TranscriptomicsTranscription profiling of human acute myeloid leukemia cell line OCI/AML2 with the anti-parasitic ivermectin
OCI AML2 cells were treated with the anti-parasitic ivermectin (single dose, two time points) in order to assess gene expression changes.
ORGANISM(S): Homo sapiens 
2010-01-06 | E-MEXP-2528 | biostudies-arrayexpress
ProteomicsIntestine proteome of Rhipicephalus microplus tick reveal key molecular features associated with resistant to ivermectin
Rhipicephalus microplus is among the critical tick parasite of cattle farming globally. However, the massive use of ivermectin last decades induced the generation of the tick-resistant population. Unfortunately, despite extensive research the mode of action of ivermectin remains unclear. Due to the...
ORGANISM(S): Rhipicephalus microplus 
2024-01-29 | PXD031231 | Pride
Lc-ms Ivermectin Sps Proteome Rhipicephalus microplus 
TranscriptomicsExpression data from Caenorhabditis elegans exposed to ivermectin
We have investigated the transcriptomic response of the model nematode Caenorhabditis elegans to ivermectin (IVM); an important anthelmintic for human and animal parasite control. The transcriptomic response of the mutant strain DA1316 avr-14(ad1302); avr-15(ad1250); glc-1(pk54), which is highly res...
ORGANISM(S): Caenorhabditis elegans 
2011-04-01 | E-GEOD-22660 | biostudies-arrayexpress
GenomicsIvermectin-exposed C.elegans (N2) transcriptomics
Transcriptomics of Ivermectin Response in Caenorhabditis elegans: integrating Abamectin Quantitative Trait Loci and Comparison to the Ivermectin-Exposed DA1316 Strain
PRJEB59331 | ENA
GenomicsIvermectin-exposed C.elegans (N2) transcriptomics
Transcriptomics of Ivermectin Response in Caenorhabditis elegans: integrating Abamectin Quantitative Trait Loci and Comparison to the Ivermectin-Exposed DA1316 Strain
PRJEB59181 | ENA
TranscriptomicsExpression data from Caenorhabditis elegans exposed to ivermectin
We have investigated the transcriptomic response of the model nematode Caenorhabditis elegans to ivermectin (IVM); an important anthelmintic for human and animal parasite control. The transcriptomic response of the mutant strain DA1316 avr-14(ad1302); avr-15(ad1250); glc-1(pk54), which is highly res...
ORGANISM(S): Caenorhabditis elegans 
2011-04-01 | GSE22660 | GEO
TranscriptomicsIvermectin inhibits the growth of esophageal squamous cell carcinoma by activating ATF4-mediated endoplasmic reticulum stress-autophagy pathway
Esophageal squamous cell carcinoma (ESCC) is one of the most common form of malignancies in the world. However, there is currently a lack of effective chemotherapeutic drugs for ESCC, and it is urgent to develop new and safe drugs for this disease. Ivermectin is a broad-spectrum antiparasitic drug w...
ORGANISM(S): Homo sapiens 
2024-12-18 | GSE201404 | GEO
GenomicsAnalyses of emerging macrocyclic lactone resistance: speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus
Subtherapeutic selection of Haemonchus contortus with ivermectin and moxidectin
PRJEB88928 | ENA
TranscriptomicsIntegrated omics profiling reveals FOXA1 and Ku70/Ku80 as the direct target of ivermectin for prostate carcinogenic inhibition
Here, we show that ivermectin suppress prostate cancer progression by inhibiting AR signaling pathway and attenuate cellular DNA damage repair capacity. We applied an integrated omics profiling including RNA-seq and Thermal proteome, that found pioneer factor Forkhead Box Protein A1 (FOXA1) and Non-...
ORGANISM(S): Homo sapiens 
2022-04-01 | GSE169356 | GEO
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