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ProteomicsAtomic-Resolution Prediction of Degrader-mediated Ternary Complex Structures by Combining Molecular Simulations with Hydrogen Deuterium Exchange
Targeted protein degradation (TPD) has emerged as a powerful approach for removing (rather than inhibiting) proteins implicated in diseases. A key step in TPD is the formation of an induced proximity complex where a degrader molecule recruits an E3 ligase to the protein of interest (POI), facilitat...
ORGANISM(S): Homo sapiens (Human) 
2022-10-01 | PXD033763 | Pride
Lc-msms Degrader prediction Hela cells Ubiquitination mapping 
ProteomicsSMARCA2, VHL Binary and Ternary Complex formation with ACBi1, PROTAC1, and PROTAC2
Interrogration of impacts on Hydrogen Deuterium Exchange of ligand binding using heterobifunctional molecules ACBi1(SiTX-0038406), PROTAC1(SiTX-0038404) and PROTAC2(SiTX-0038405) on target proteins SMARCA2 and VHL both in the binary and Ternary modes.
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD033849 | Pride
Hdx-ms 
UnknownCharacterization of the Anopheles gambiae octopamine receptor and discovery of potential agonists and antagonists using a combined computational-experimental approach.
Not available
S-EPMC4253978 | biostudies-literature
UnknownMutational Landscape of Bladder Cancer in Mexican Patients: KMT2D Mutations and chr11q15.5 Amplifications Are Associated with Muscle Invasion.
Not available
S-EPMC9866210 | biostudies-literature
UnknownModeling conformational ensembles of slow functional motions in Pin1-WW.
Not available
S-EPMC2996313 | biostudies-literature
UnknownGenomic landscape of early-stage prostate adenocarcinoma in Mexican patients: an exploratory study.
Not available
S-EPMC11358564 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
UnknownPredicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry.
Not available
S-EPMC9537307 | biostudies-literature
UnknownThe Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design.
Not available
S-EPMC7563269 | biostudies-literature
UnknownSequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.
Not available
S-EPMC3379583 | biostudies-literature
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