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Transcriptional profiling of J7774A.1 cells treated with ManLAM ( 5ug/ml) for 6 h in the absence or presence of GW9662 J774A.1 cells were treated wit ManLAM either in the absence or presence of GW9662 for 6 h followed by total RNA isolation. Total RNA was labelled with Agilent’s quick-Amp labelling...
ORGANISM(S): Mus musculus 
The goal of the experiment was to demonstrate if the overexpression of human-Prune-1 in Triple Negative breast cancer cells induces M2-polarization of macrophages in vitro. For this purpose, murine primary cells from breast tumor developed by Genetically Engineered Mouse Models (GEMMs) of TNBC (i.e....
ORGANISM(S): Mus musculus 
The aim of this project is to observe the effect of 5 μM rhein treatment on the acetylation level of NLRP3 activated macrophages. We primed J774A.1 cells with 100ng/mL LPS for 12 hours followed by 5μM rhein treatment for 30 minutes. Finally, the cells were stimulated with 4 mM ATP for 30 min to trig...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD044992 | Pride
To investigate the mechanisms of UDCA reduce inflammation effects in J774A.1 cells induced inflammation by LPS
Phagocytosis represents a mechanism used by macrophages to remove pathogens and cellular debris. Recent evidence suggested that amino acid or glucose deprivation may cause an increase in phagocytosis of heat-inactivated Escherichia coli and Staphylococcus aureus by macrophages, but not the uptake of...
ORGANISM(S): Mus musculus 
The objective of this study was to investigate the effects of UDCA on J774A.1 cells induced inflammation by LPS. The control group treated with LPS and the UDCA group treated with both LPS and UDCA. Compared with control group, the UDCA group could reduce the inflammation effects in J774A.1 cells.
ORGANISM(S): Mus musculus 
2023-02-08 | GSE174489 | GEO
Genomics
Transcriptome of OMV-stimulated J774A.1 cells
Effect of Mip inhibition on J774A.1 macrophage immune response during Burkholderia pseudomallei infection
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