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UnknownCombined biology-guided radiotherapy and Lutetium PSMA theranostics treatment in metastatic castrate-resistant prostate cancer.
Not available
S-EPMC10040757 | biostudies-literature
UnknownSafety of Lutetium-177 prostate-specific membrane antigen-617 (PSMA-617) radioligand therapy in the setting of severe renal impairment: a case report and literature review.
Not available
S-EPMC10262655 | biostudies-literature
ProteomicsModeling cooperative tumor suppression in the p53 target gene network with in vivo genetic screens and multi-omics
The tumor suppressor TP53 is the most frequently mutated gene in human cancer. TP53 encodes a transcriptional activator that induces numerous downstream target genes, but those genes critical for tumor suppression remain elusive. To shed light on the downstream target genes important for tumor suppr...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-17 | PXD047240 | Pride
Mouse Embryonic fibroblast P53 
UnknownSingle-arm prospective interventional study assessing feasibility of using gallium-68 ventilation and perfusion PET/CT to avoid functional lung in patients with stage III non-small cell lung cancer.
Not available
S-EPMC7733178 | biostudies-literature
UnknownRadiological, Pathological, and Surgical Outcomes with Neoadjuvant Cemiplimab for Stage II-IV Cutaneous Squamous Cell Carcinoma in the Deep Sequencing in Cutaneous Squamous Cell Carcinomas (DISCERN) Trial.
Not available
S-EPMC12110075 | biostudies-literature
TranscriptomicsWidespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
Transfected siRNAs and miRNAs regulate numerous transcripts that have only limited complementarity to the active strand of the RNA duplex. This process reflects natural target regulation by miRNAs, but is an unintended (â??off-targetâ??) consequence of siRNA-mediated silencing. Here we demonstrate...
ORGANISM(S): Homo sapiens 
2006-09-12 | E-GEOD-5814 | biostudies-arrayexpress
TranscriptomicsmicroRNA-like off-target transcript regulation by siRNAs
siRNAs mediate sequence-specific gene silencing in cultured mammalian cells but also silence unintended transcripts. Many siRNA off-target transcripts match the guide-strand ‘‘seed region,’’ similar to the way microRNAs match their target sites. The extent to which this seed-matched, microRNA-like, ...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-14073 | biostudies-arrayexpress
ProteomicsIdentification of biomarkers for PKD1 using urinary exosomes
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either the PKD1 or PKD2 gene, encoding the proteins polycystin?1 (PC1) or polycystin?2 (PC2) respectively. PC1 and PC2 are secreted on urinary exosome?like vesicles (ELVs)...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-01 | MSV000079547 | MassIVE
UnknownSFRP4 drives invasion in gastric cancer and is an early predictor of recurrence.
Not available
S-EPMC8064978 | biostudies-literature
TranscriptomicsSomatic cells in testes
Gene expression profiles of somatic cells of fetal and adult testis. To identify genes developmentally regulated in the somatic cells of the testis, serial analysis of gene expression (SAGE) has been used to generate gene expression profiles from these cells in the fetal and adult mouse. To avoid g...
ORGANISM(S): Mus musculus 
2003-05-06 | E-GEOD-366 | biostudies-arrayexpress
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