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TranscriptomicsTranscription profiling of mouse peripheral T cells subsets: T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells after treatment with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressing retroviral vectors
This data set is comprised of all peripheral (pooled lymph nodes and spleen) T cell subsets presented in this manuscript. These include T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells from mice treated with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressi...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7280 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization and transcription profiling of human and mouse T cells in differentiation
ChIP-Chip for T-bet and GATA-3 in human Th1 and Th2 cells, gene expression profiling of human Th1 and Th2 cells and of T-cells from T-bet-deficient mice,
ORGANISM(S): Homo sapiens 
2009-10-26 | E-TABM-759 | biostudies-arrayexpress
TranscriptomicsT-bet and GATA-3 act in combination through distal regulatory elements across the genome
Gene expression measurements in Thp, Th1 and Th2 cells polarised from naIve CD4+ T-cells isolated from wildtype and T-bet fl/fl x Cd4-Cre BALB/c mice or from WT and Gata-3 fl/fl x Tnfrsf4-Cre C57BL/6 mice.
ORGANISM(S): Mus musculus 
2012-10-29 | E-TABM-1187 | biostudies-arrayexpress
TranscriptomicsA single-round of antigen receptor signaling programs naïve B cells to receive T cell help
To simulate transient B cell activation that is the likely initiator of T-dependent responses, we examined the molecular and functional consequences of a single-round of immunoglobulin M (IgM) signaling. This form of activation triggered early cytosolic signaling and transcription factor NF-kB activ...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-20477 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of in vitro derived induced and natural FOXP3+ regulatory T cells and ex-iTreg cells in the mouse
Induced Treg (iTreg) cells are essential for tolerance and can be used therapeutically, yet their stability in vivo and mechanisms of suppression are unresolved. Here, we used a treatment model of colitis to examine the role of autologous IL-10 in iTreg cell function. Mice treated with IL-10+/+ iTr...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35543 | biostudies-arrayexpress
TranscriptomicsAlternative splicing controlled by heterogeneous nuclear ribonucleoprotein L (hnRNP L) regulates development, proliferation and migration of thymic pre-T cells
The regulation of post-transcriptional modifications of pre-mRNA by alternative splicing is important for cellular function, development and immunity The receptor tyrosine phosphatase CD45, which is expressed on all hematopoietic cells, is known for its role in the development and activation of T ce...
ORGANISM(S): Mus musculus 
2012-04-23 | E-GEOD-33306 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4 regulatory T cells that express either CD45RA or CD45RO
CD4 T cells taken from 6 donors were sorted into CD25hi CD45RA+ (na�ve Treg), CD25hi CD45RO+ (memory Treg), CD25- CD45RA+ (na�ve responder) and CD25- CD45RO+ (memory responder) populations.

RNA was extracted (Ambion RNAqueous), amplified (SMART), labelled with cy3, mixed with cy5 labelle...
ORGANISM(S): Homo sapiens 
2009-10-05 | E-MEXP-2372 | biostudies-arrayexpress
TranscriptomicsBAC-trap studies of Purkinje cells in normal and FMR1 mutant mice
The molecular mechanism(s) leading to Purkinje neuron loss in the neurodegenerative disorder Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) are limited by the complex morphology of this cell type. Purkinje neurons are notoriously difficult to isolate and maintain in culture presenting considera...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-57034 | biostudies-arrayexpress
TranscriptomicsTGF-beta/Smad3-dependent gene expression analysis in naive CD4 T cells
Investigation of transcript level modulation in unstimulated and TGF-beta treated (with or without superimposed T-cell receptor and CD28 stimulation) naive CD4 T cells from wild type or Smad3-deficient littermate mice. Smad3 is a critical signaling molecule and transcription factor downstream of TGF...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-40494 | biostudies-arrayexpress
TranscriptomicsSDF-1 chemokine signaling modulates the apoptotic responses of clathrin-depleted DT40 cells
The cell line DKO-S is derived form chicken B-Cell DT40 cells where the clathrin heavy-chain has been placed under the control of a tetracycline-regulatable promoter (Tet-Off). The originally derived cell-line DKO-S underwent apoptosis when clathrin expression was repressed. A cell line, DKO-R, der...
ORGANISM(S): Gallus gallus 
2014-05-07 | E-GEOD-57328 | biostudies-arrayexpress
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