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ProteomicsIdentification of non-overlapping functions between adaptor proteins NCK1 and NCK2
Signals from cell surface receptors are often relayed via adaptor proteins. NCK1 and NCK2 are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a remodelling of the actin cytoskeleton. Evidence from gene inactivation in mouse suggest that NCK1 and NCK2 are functionally redu...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD008824 | Pride
Mass spectrometry Nck adaptors Specificity 
ProteomicsThe ShcA adapter protein cooperates with LPP to mediate adhesion dynamics and invadopodia formation
ShcA and Lipoma Preferred Partner (LPP) are mediators of TGFβ-induced breast cancer cell migration and invasion. Reduced expression of either protein results in diminished breast cancer lung metastasis. Total internal reflection fluorescence (TIRF) microscopy reveals that TGFβ enhances the assembly ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-27 | PXD018265 | Pride
Invasion Shca Adhesion Adaptor 
ProteomicsTargeting of Tumor Cells by the Adenovirus E4orf4 protein via Par3 Polarity Protein-Regulated Nuclear Envelope Rupture
The protein product of the Early region 4 open reading frame 4 (E4orf4) of human adenovirus 2 is reported to exhibit a tumor-selective cell killing activity. Here, we show that E4orf4’s tumoricidal activity correlated with changes in perinuclear actomyosin contractility that are controlled by an in...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014329 | Pride
Lamin a/c Polarity proteins Actin Live cell dynamics Nuclear bleb E4orf4 
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