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TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Sh...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-41718 | biostudies-arrayexpress
ProteomicsThe ShcA adapter protein cooperates with LPP to mediate adhesion dynamics and invadopodia formation
ShcA and Lipoma Preferred Partner (LPP) are mediators of TGFβ-induced breast cancer cell migration and invasion. Reduced expression of either protein results in diminished breast cancer lung metastasis. Total internal reflection fluorescence (TIRF) microscopy reveals that TGFβ enhances the assembly ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-27 | PXD018265 | Pride
Invasion Shca Adhesion Adaptor 
TranscriptomicsShcA is a Paracrine Integrator of the Adaptive Immune Response during Breast Cancer Progression
Using transgenic mouse models of breast cancer, we demonstrate that loss of ShcA signaling within mammary tumors results in extensive CD4+ T cell infiltration, activation and induction of a humoral immune response. Our studies reveal that ShcA signaling during early breast cancer progression is requ...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-18996 | biostudies-arrayexpress
TranscriptomicsShcA is a Paracrine Integrator of the Adaptive Immune Response during Breast Cancer Progression
Using transgenic mouse models of breast cancer, we demonstrate that loss of ShcA signaling within mammary tumors results in extensive CD4+ T cell infiltration, activation and induction of a humoral immune response. Our studies reveal that ShcA signaling during early breast cancer progression is requ...
ORGANISM(S): Mus musculus 
2010-10-12 | GSE18996 | GEO
UnknownShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies.
Not available
S-EPMC5748910 | biostudies-literature
UnknownThe PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1.
Not available
S-EPMC2837165 | biostudies-literature
TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Shc...
ORGANISM(S): Mus musculus 
2013-08-07 | GSE41718 | GEO
UnknownShcA signalling is essential for tumour progression in mouse models of human breast cancer.
Not available
S-EPMC2274931 | biostudies-literature
UnknownThe ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function.
Not available
S-EPMC3109628 | biostudies-literature
UnknownShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.
Not available
S-EPMC1636838 | biostudies-literature
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