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GenomicsThe ChIP-Sequence data of STAT92E in Drosophila adult intestines
JAK/STAT pathway plays important roles in controlling Drosophila intestinal homeostasis and regulating the ISC proliferation and differentiation. However,the downstream targets of its transcription factor-STAT92E remain largely unknown.To further identify the regualtory mechanisms of the JAK/STAT pa...
ORGANISM(S): Drosophila melanogaster 
2015-05-12 | E-GEOD-67346 | biostudies-arrayexpress
TranscriptomicsExpression profiling in the Drosophila eye reveals unexpected repression of Notch signaling by the JAK/STAT pathway
Although the JAK/STAT pathway regulates numerous processes in vertebrates and invertebrates through modulating transcription, its functionally-relevant transcriptional targets remain largely unknown. With one jak and one stat (stat92E), Drosophila provides a powerful system for finding new JAK/STAT ...
ORGANISM(S): Drosophila melanogaster 
2009-08-01 | E-GEOD-15868 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54644 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54645 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Kc167 cell line
The consitutive activation of the JAK/STAT signalling cascade is reponsible for the majority of meyoproliferative disorders in humans, a disease that is also conserved in Drosophila. A gain-of-function mutation in the Drosophila JAK kinase leads to blood cell (haemocyte) overproliferation which even...
ORGANISM(S): Drosophila melanogaster 
2009-09-12 | E-GEOD-15584 | biostudies-arrayexpress
UnknownJAK-STAT in lipid metabolism of adipocytes.
Not available
S-EPMC3906428 | biostudies-literature
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54646 | biostudies-arrayexpress
UnknownEvolution of the JAK-STAT pathway.
Not available
S-EPMC3670263 | biostudies-literature
GenomicsEfficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia
Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype of T-ALL characterized by a unique immunophenotype and genomic profile as well as a high rate of induction failure. Frequent mutations in cytokine receptor and JAK/STAT signaling pathways led us to hypoth...
EGAS00001001146 | EGA
ModelsYamada2003_JAK_STAT_SOCS1_knockout
NCBS Curation Comments: This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1...
2024-09-02 | BIOMD0000000094 | BioModels
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