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ProteomicsDevelopment of resistance to type II JAK2 inhibition in MPN depends on AXL kinase and is targetable
Purpose: Myeloproliferative neoplasms (MPN) dysregulate JAK2 signaling. Since clinical JAK2 inhibitors have limited disease-modifying effects, type II JAK2 inhibitors such as CHZ868 stabilizing inactive JAK2 and reducing MPN clones, gain interest. We studied whether MPN cells escape from type ll inh...
ORGANISM(S): Homo sapiens (Human) 
2023-11-07 | PXD039419 | Pride
: lfq Resistance Myeloproliferative neoplasms Mapk Chz868 Axl Phosphoproteomics Dda Jak2 inhibition 
TranscriptomicsCooperative Epigenetic Modulation by Cancer Amplicon Genes
Amplification of a ~2.5 megabase region on chromosome 9p24 is frequent in both primary mediastinal B-cell lymphoma (PMBL) and Hodgkin's lymphoma (HL). To identify the oncogenic genes in this interval, we created a RNA interference library targeting amplicon genes. A genetic screen using this library...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-20988 | biostudies-arrayexpress
ProteomicsSplicing factor Ybx1 maintains persistent Jak2-mutated neoplasms via Mknk1-ERK-signaling
Janus kinases (Jak) mediate cytokine, hormone and growth factor responses in hematopoietic cells. Jak2 is one of the most frequently mutated genes in the aging hematopoietic system and in hematopoietic cancers. Mutations in Jak constitutively activate downstream signaling and are drivers of myelopro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-20 | PXD006921 | Pride
Mpn Phosphoproteome Jak2 Hematological malignancy Splicing factor Erksignaling Ybx1 
TranscriptomicsThe HDAC inhibitor Givinostat modulates key hematopoietic genes in JAK2V617F cells, affecting proliferation, differentiation and apoptosis
We investigated the mechanism of action of the HDAC inhibitor Givinostat in JAK2V617F cells. We confirm that the drug inhibits colony formation and proliferation and induces apoptosis at doses 2-3 fold lower in JAK2V617F (HEL, UKE1 and SET2) compared to JAK2 wild type cell lines (K562, KU812, THP1 a...
ORGANISM(S): Homo sapiens 
2012-07-16 | E-GEOD-27615 | biostudies-arrayexpress
TranscriptomicsIdentification of potential new therapeutic approaches for JAK2 V617F mutant patients
Myelofibrosis is often associated with the myeloproliferative neoplasms and expression of oncogenic JAK2 mutants. Patients with myelofibrosis have diminished quality of life due to systemic symptoms arising from fibrotic changes in the bone marrow. The introduction of the JAK2 inhibitor, ruxolitinib...
ORGANISM(S): Homo sapiens 
2022-08-11 | E-MTAB-11653 | biostudies-arrayexpress
UnknownTherapy with JAK2 inhibitors for myeloproliferative neoplasms.
Not available
S-EPMC4406395 | biostudies-literature
TranscriptomicsGenomic profiling of neoplasms developed in SEC31A-JAK2 expressing mice
The genetics of classical Hodgkin lymphoma (cHL) is poorly understood. The finding of a JAK2-involving t(4;9)(q21;p24) in one case of cHL prompted us to characterize this translocation on a molecular level and to determine the prevalence of JAK2 rearrangements in cHL. We showed that the t(4;9)(q21;p...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22404 | biostudies-arrayexpress
ProteomicsA novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors
Interleukin-12 (IL12) is a pro-inflammatory cytokine with potent anti-cancer activity. Attempts to develop recombinant IL12 as a biopharmaceutical have been hampered by severe toxicity, observed already at daily dose of 500 ng/kg. The antibody-based delivery of IL12 significantly increases the thera...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-25 | PXD047339 | Pride
Tumor targeting Mouse Liver Tumor Jak2 inhibitors 
UnknownJAK2 inhibitors for myeloproliferative neoplasms: what is next?
Not available
S-EPMC5510786 | biostudies-literature
UnknownCombined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.
Not available
S-EPMC3898474 | biostudies-literature
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