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ProteomicsThrombospondin-4 is a soluble dermal signal that selectively promotes fibroblast migration and keratinocyte proliferation for skin regeneration and wound healing
Thrombosponin-4 (THBS4) is a non-structural extracellular matrix molecule associated with tissue regeneration and a variety of pathological processes characterized by increased cell proliferation and migration. However, the mechanisms of how THBS4 regulates cell behaviour as well as the pathways con...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027364 | Pride
Burns Thrombospondin-4 Wound healing Psoriasis Fibroblasts Skin regeneration 
ProteomicsOlfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration
Olfactomedin-4 (OLFM4) is an olfactomedin-domain-containing glycoprotein which regulates cell adhesion, proliferation, gastrointestinal inflammation, innate immunity and cancer metastasis. In the present study investigated its role in skin regeneration and wound healing. We found that OLFM4 expressi...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029881 | Pride
Burns Keratinocytes Wound healing Psoriasis Olfactomedin-4 Skin regeneration 
ProteomicsProliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis
Atopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-29 | PXD037593 | Pride
Thbs4 Thrombospondin-4 Skin Keratinocytes Atopic dermatitis 
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