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ProteomicsProliferation, migration and inflammation-related signaling pathways activated in THBS4-stimulated keratinocytes characterize both wound healing and atopic dermatitis
Atopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-29 | PXD037593 | Pride
Thbs4 Thrombospondin-4 Skin Keratinocytes Atopic dermatitis 
GenomicsStimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes
Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes
PRJNA882338 | ENA
UnknownPotential Role of PDGFRβ-Associated THBS4 in Colorectal Cancer Development.
Not available
S-EPMC7564555 | biostudies-literature
TranscriptomicsStimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes
Atopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was ...
ORGANISM(S): Homo sapiens 
2024-12-28 | GSE213737 | GEO
ProteomicsThrombospondin-4 is a soluble dermal signal that selectively promotes fibroblast migration and keratinocyte proliferation for skin regeneration and wound healing
Thrombosponin-4 (THBS4) is a non-structural extracellular matrix molecule associated with tissue regeneration and a variety of pathological processes characterized by increased cell proliferation and migration. However, the mechanisms of how THBS4 regulates cell behaviour as well as the pathways con...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027364 | Pride
Burns Thrombospondin-4 Wound healing Psoriasis Fibroblasts Skin regeneration 
UnknownDNA Methylation in INA, NHLH2, and THBS4 Is Associated with Metastatic Disease in Renal Cell Carcinoma.
Not available
S-EPMC8750163 | biostudies-literature
UnknownTranscriptome sequencing revealed that lymph node metastasis of papillary thyroid microcarcinoma is associated with high THBS4 expression and PDGFRA+ cancer-associated fibroblasts.
Not available
S-EPMC12037473 | biostudies-literature
UnknownSerum Proteins, HMMR, NXPH4, PITX1 and THBS4; A Panel of Biomarkers for Early Diagnosis of Hepatocellular Carcinoma.
Not available
S-EPMC9027255 | biostudies-literature
UnknownTHBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection.
Not available
S-EPMC8386559 | biostudies-literature
TranscriptomicsThrombospondin-4 is a soluble dermal inflammatory signal that activates the fibroblast migration for skin regeneration and wound healing
The present study aimed to investigate the role of Thbs4 in skin regeneration and elucidate its effects on cellular responses. Here we show that Thbs4 expression is upregulated in healing skin wounds and wound healing can be promoted by the application of recombinant Thbs4 protein. Thbs4 was shown t...
ORGANISM(S): Homo sapiens 
2021-10-13 | GSE179969 | GEO
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